Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4

Free fatty acids (FFAs) play important roles in cardiovascular disease. Studies have shown that it is an important way for FAs to exert biological effects through their own receptors besides directly participating biochemical reaction in body. Free fatty acid receptor 2 (FFA2) can be activated by sh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hui Gao, Kunming Tian, Xiaojun Feng, Mengqing Yan, Chen Gao, Yisheng Jiang, Chenhao Zhu, Huzhe Zhu, Xueping Liu, Yingfu Peng
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	FFA2 Cardiac hypertrophy GATA4 STAT3 ERK1/2 Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ef17cf5f6f324c03a9febe2ebb425924
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ef17cf5f6f324c03a9febe2ebb425924
record_format	dspace
spelling	oai:doaj.org-article:ef17cf5f6f324c03a9febe2ebb4259242021-11-28T04:32:15ZFree fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA42213-453010.1016/j.fshw.2021.11.022https://doaj.org/article/ef17cf5f6f324c03a9febe2ebb4259242022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221345302100118Xhttps://doaj.org/toc/2213-4530Free fatty acids (FFAs) play important roles in cardiovascular disease. Studies have shown that it is an important way for FAs to exert biological effects through their own receptors besides directly participating biochemical reaction in body. Free fatty acid receptor 2 (FFA2) can be activated by short-chain FAs and is involved in inflammatory reactions and lipid accumulation. Since the known pathological changes caused by FFA2 are also implicated in cardiac hypertrophy, we hypothesized that FFA2 might be pathogenic in cardiac hypertrophy. This paper showed that FFA2 expression significantly increased in cardiac hypertrophy in vivo and in vitro. FFA2 agonist 4-CMTB or TUG-1375 promoted the expression of the hypertrophy markers ANF and BNP and increased cell surface area in vitro, which was further strengthened by FFA2 overexpression, suggesting that FFA2 might contribute to cardiomyocyte hypertrophy. Furthermore, 4-CMTB treatment or FFA2 overexpression combined with 4-CMTB treatment elevated the phosphorylation and transcriptional activity of GATA4 and STAT3, which were inhibited by an ERK1/2 inhibitor, and GATA4 and STAT3 knockdown inhibited the elevation of hypertrophy biomarkers in cardiomyocytes treated with 4-CMTB. Taken together, these data indicate that FFA2 can enhance cardiomyocyte hypertrophy by activating STAT3 and GATA4 via ERK1/2, providing a potential new target for therapy.Hui GaoKunming TianXiaojun FengMengqing YanChen GaoYisheng JiangChenhao ZhuHuzhe ZhuXueping LiuYingfu PengKeAi Communications Co., Ltd.articleFFA2Cardiac hypertrophyGATA4STAT3ERK1/2Nutrition. Foods and food supplyTX341-641ENFood Science and Human Wellness, Vol 11, Iss 2, Pp 405-417 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	FFA2 Cardiac hypertrophy GATA4 STAT3 ERK1/2 Nutrition. Foods and food supply TX341-641
spellingShingle	FFA2 Cardiac hypertrophy GATA4 STAT3 ERK1/2 Nutrition. Foods and food supply TX341-641 Hui Gao Kunming Tian Xiaojun Feng Mengqing Yan Chen Gao Yisheng Jiang Chenhao Zhu Huzhe Zhu Xueping Liu Yingfu Peng Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4
description	Free fatty acids (FFAs) play important roles in cardiovascular disease. Studies have shown that it is an important way for FAs to exert biological effects through their own receptors besides directly participating biochemical reaction in body. Free fatty acid receptor 2 (FFA2) can be activated by short-chain FAs and is involved in inflammatory reactions and lipid accumulation. Since the known pathological changes caused by FFA2 are also implicated in cardiac hypertrophy, we hypothesized that FFA2 might be pathogenic in cardiac hypertrophy. This paper showed that FFA2 expression significantly increased in cardiac hypertrophy in vivo and in vitro. FFA2 agonist 4-CMTB or TUG-1375 promoted the expression of the hypertrophy markers ANF and BNP and increased cell surface area in vitro, which was further strengthened by FFA2 overexpression, suggesting that FFA2 might contribute to cardiomyocyte hypertrophy. Furthermore, 4-CMTB treatment or FFA2 overexpression combined with 4-CMTB treatment elevated the phosphorylation and transcriptional activity of GATA4 and STAT3, which were inhibited by an ERK1/2 inhibitor, and GATA4 and STAT3 knockdown inhibited the elevation of hypertrophy biomarkers in cardiomyocytes treated with 4-CMTB. Taken together, these data indicate that FFA2 can enhance cardiomyocyte hypertrophy by activating STAT3 and GATA4 via ERK1/2, providing a potential new target for therapy.
format	article
author	Hui Gao Kunming Tian Xiaojun Feng Mengqing Yan Chen Gao Yisheng Jiang Chenhao Zhu Huzhe Zhu Xueping Liu Yingfu Peng
author_facet	Hui Gao Kunming Tian Xiaojun Feng Mengqing Yan Chen Gao Yisheng Jiang Chenhao Zhu Huzhe Zhu Xueping Liu Yingfu Peng
author_sort	Hui Gao
title	Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4
title_short	Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4
title_full	Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4
title_fullStr	Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4
title_full_unstemmed	Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4
title_sort	free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating stat3 and gata4
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/ef17cf5f6f324c03a9febe2ebb425924
work_keys_str_mv	AT huigao freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4 AT kunmingtian freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4 AT xiaojunfeng freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4 AT mengqingyan freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4 AT chengao freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4 AT yishengjiang freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4 AT chenhaozhu freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4 AT huzhezhu freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4 AT xuepingliu freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4 AT yingfupeng freefattyacidreceptor2promotescardiomyocytehypertrophybyactivatingstat3andgata4
_version_	1718408354244591616

Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4

Ejemplares similares