Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy
Interleukin-2 can induce an anti-tumour response, but is associated with toxicity. Here, the authors demonstrate that an engineered interleukin-2 promotes intratumoral T regulatory cell depletion while enhancing effective anti-tumour CD8+ T cell responses that result in potent tumor suppression.
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Nature Portfolio
2020
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oai:doaj.org-article:ef1801862b2840b0a440db03c657db662021-12-02T17:32:43ZBempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy10.1038/s41467-020-14471-12041-1723https://doaj.org/article/ef1801862b2840b0a440db03c657db662020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14471-1https://doaj.org/toc/2041-1723Interleukin-2 can induce an anti-tumour response, but is associated with toxicity. Here, the authors demonstrate that an engineered interleukin-2 promotes intratumoral T regulatory cell depletion while enhancing effective anti-tumour CD8+ T cell responses that result in potent tumor suppression.Meenu SharmaHiep KhongFaisal Fa’akSalah-Eddine BentebibelLouise M. E. JanssenBrent C. ChessonCaitlin A. CreasyMarie-Andrée ForgetLaura Maria S. KahnBarbara PazdrakBinisha KarkiYared HailemichaelManisha SinghChristina ViandenSrinivas VennamUddalak BharadwajDavid J. TweardyCara HaymakerChantale BernatchezShixia HuangKimal RajapaksheCristian CoarfaMichael E. HurwitzMario SznolPatrick HwuUte HochMurali AddepalliDeborah H. CharychJonathan ZalevskyAdi DiabWillem W. OverwijkNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Meenu Sharma Hiep Khong Faisal Fa’ak Salah-Eddine Bentebibel Louise M. E. Janssen Brent C. Chesson Caitlin A. Creasy Marie-Andrée Forget Laura Maria S. Kahn Barbara Pazdrak Binisha Karki Yared Hailemichael Manisha Singh Christina Vianden Srinivas Vennam Uddalak Bharadwaj David J. Tweardy Cara Haymaker Chantale Bernatchez Shixia Huang Kimal Rajapakshe Cristian Coarfa Michael E. Hurwitz Mario Sznol Patrick Hwu Ute Hoch Murali Addepalli Deborah H. Charych Jonathan Zalevsky Adi Diab Willem W. Overwijk Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy |
| description |
Interleukin-2 can induce an anti-tumour response, but is associated with toxicity. Here, the authors demonstrate that an engineered interleukin-2 promotes intratumoral T regulatory cell depletion while enhancing effective anti-tumour CD8+ T cell responses that result in potent tumor suppression. |
| format |
article |
| author |
Meenu Sharma Hiep Khong Faisal Fa’ak Salah-Eddine Bentebibel Louise M. E. Janssen Brent C. Chesson Caitlin A. Creasy Marie-Andrée Forget Laura Maria S. Kahn Barbara Pazdrak Binisha Karki Yared Hailemichael Manisha Singh Christina Vianden Srinivas Vennam Uddalak Bharadwaj David J. Tweardy Cara Haymaker Chantale Bernatchez Shixia Huang Kimal Rajapakshe Cristian Coarfa Michael E. Hurwitz Mario Sznol Patrick Hwu Ute Hoch Murali Addepalli Deborah H. Charych Jonathan Zalevsky Adi Diab Willem W. Overwijk |
| author_facet |
Meenu Sharma Hiep Khong Faisal Fa’ak Salah-Eddine Bentebibel Louise M. E. Janssen Brent C. Chesson Caitlin A. Creasy Marie-Andrée Forget Laura Maria S. Kahn Barbara Pazdrak Binisha Karki Yared Hailemichael Manisha Singh Christina Vianden Srinivas Vennam Uddalak Bharadwaj David J. Tweardy Cara Haymaker Chantale Bernatchez Shixia Huang Kimal Rajapakshe Cristian Coarfa Michael E. Hurwitz Mario Sznol Patrick Hwu Ute Hoch Murali Addepalli Deborah H. Charych Jonathan Zalevsky Adi Diab Willem W. Overwijk |
| author_sort |
Meenu Sharma |
| title |
Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy |
| title_short |
Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy |
| title_full |
Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy |
| title_fullStr |
Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy |
| title_full_unstemmed |
Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy |
| title_sort |
bempegaldesleukin selectively depletes intratumoral tregs and potentiates t cell-mediated cancer therapy |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ef1801862b2840b0a440db03c657db66 |
| work_keys_str_mv |
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| _version_ |
1718380220901228544 |