Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.

Astroviruses are a known cause of human diarrhea. Recently the highly divergent astrovirus MLB1 (MLB1) was identified in a stool sample from a patient with diarrhea. It has subsequently been detected in stool from individuals with and without diarrhea. To determine whether MLB1 is associated with di...

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Autores principales:	Lori R Holtz, Irma K Bauer, Priya Rajendran, Gagandeep Kang, David Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef1c21e3dfbd4863b80fac3eeffb08ab
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spelling	oai:doaj.org-article:ef1c21e3dfbd4863b80fac3eeffb08ab2021-11-18T07:32:37ZAstrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.1932-620310.1371/journal.pone.0028647https://doaj.org/article/ef1c21e3dfbd4863b80fac3eeffb08ab2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22174853/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Astroviruses are a known cause of human diarrhea. Recently the highly divergent astrovirus MLB1 (MLB1) was identified in a stool sample from a patient with diarrhea. It has subsequently been detected in stool from individuals with and without diarrhea. To determine whether MLB1 is associated with diarrhea, we conducted a case control study of MLB1. In parallel, the prevalence of the classic human astroviruses (HAstVs) was also determined in the same case control cohort. 400 cases and 400 paired controls from a longitudinal birth cohort in Vellore, India were analyzed by RT-PCR. While HAstVs were associated with diarrhea (p = 0.029) in this cohort, MLB1 was not; 14 of the controls and 4 cases were positive for MLB1. Furthermore, MLB1 viral load did not differ significantly between the cases and controls. The role of MLB1 in human health still remains unknown and future studies are needed.Lori R HoltzIrma K BauerPriya RajendranGagandeep KangDavid WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e28647 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lori R Holtz Irma K Bauer Priya Rajendran Gagandeep Kang David Wang Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.
description	Astroviruses are a known cause of human diarrhea. Recently the highly divergent astrovirus MLB1 (MLB1) was identified in a stool sample from a patient with diarrhea. It has subsequently been detected in stool from individuals with and without diarrhea. To determine whether MLB1 is associated with diarrhea, we conducted a case control study of MLB1. In parallel, the prevalence of the classic human astroviruses (HAstVs) was also determined in the same case control cohort. 400 cases and 400 paired controls from a longitudinal birth cohort in Vellore, India were analyzed by RT-PCR. While HAstVs were associated with diarrhea (p = 0.029) in this cohort, MLB1 was not; 14 of the controls and 4 cases were positive for MLB1. Furthermore, MLB1 viral load did not differ significantly between the cases and controls. The role of MLB1 in human health still remains unknown and future studies are needed.
format	article
author	Lori R Holtz Irma K Bauer Priya Rajendran Gagandeep Kang David Wang
author_facet	Lori R Holtz Irma K Bauer Priya Rajendran Gagandeep Kang David Wang
author_sort	Lori R Holtz
title	Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.
title_short	Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.
title_full	Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.
title_fullStr	Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.
title_full_unstemmed	Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.
title_sort	astrovirus mlb1 is not associated with diarrhea in a cohort of indian children.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ef1c21e3dfbd4863b80fac3eeffb08ab
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Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.

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