Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

A critical determinant of tumor eradication by adoptive immunotherapy is the tumor associated antigen recognized by cytotoxic T lymphocytes. Here the authors generate ex vivo autologous cytotoxic T lymphocytes by exposure to antigens induced by DNA demethylation and report the results of a phase 1 t...

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Autores principales:	Alexei F. Kirkin, Karine N. Dzhandzhugazyan, Per Guldberg, Johnny Jon Fang, Rikke S. Andersen, Christina Dahl, Jann Mortensen, Tim Lundby, Aase Wagner, Ian Law, Helle Broholm, Line Madsen, Christer Lundell-Ek, Morten F. Gjerstorff, Henrik J. Ditzel, Martin R. Jensen, Walter Fischer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef1dc53a886a4a839839ded99353ddc1
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spelling	oai:doaj.org-article:ef1dc53a886a4a839839ded99353ddc12021-12-02T17:31:16ZAdoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells10.1038/s41467-018-03217-92041-1723https://doaj.org/article/ef1dc53a886a4a839839ded99353ddc12018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03217-9https://doaj.org/toc/2041-1723A critical determinant of tumor eradication by adoptive immunotherapy is the tumor associated antigen recognized by cytotoxic T lymphocytes. Here the authors generate ex vivo autologous cytotoxic T lymphocytes by exposure to antigens induced by DNA demethylation and report the results of a phase 1 trial of 25 patients with recurrent glioblastoma multiforme with tumor regression in three patients.Alexei F. KirkinKarine N. DzhandzhugazyanPer GuldbergJohnny Jon FangRikke S. AndersenChristina DahlJann MortensenTim LundbyAase WagnerIan LawHelle BroholmLine MadsenChrister Lundell-EkMorten F. GjerstorffHenrik J. DitzelMartin R. JensenWalter FischerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexei F. Kirkin Karine N. Dzhandzhugazyan Per Guldberg Johnny Jon Fang Rikke S. Andersen Christina Dahl Jann Mortensen Tim Lundby Aase Wagner Ian Law Helle Broholm Line Madsen Christer Lundell-Ek Morten F. Gjerstorff Henrik J. Ditzel Martin R. Jensen Walter Fischer Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells
description	A critical determinant of tumor eradication by adoptive immunotherapy is the tumor associated antigen recognized by cytotoxic T lymphocytes. Here the authors generate ex vivo autologous cytotoxic T lymphocytes by exposure to antigens induced by DNA demethylation and report the results of a phase 1 trial of 25 patients with recurrent glioblastoma multiforme with tumor regression in three patients.
format	article
author	Alexei F. Kirkin Karine N. Dzhandzhugazyan Per Guldberg Johnny Jon Fang Rikke S. Andersen Christina Dahl Jann Mortensen Tim Lundby Aase Wagner Ian Law Helle Broholm Line Madsen Christer Lundell-Ek Morten F. Gjerstorff Henrik J. Ditzel Martin R. Jensen Walter Fischer
author_facet	Alexei F. Kirkin Karine N. Dzhandzhugazyan Per Guldberg Johnny Jon Fang Rikke S. Andersen Christina Dahl Jann Mortensen Tim Lundby Aase Wagner Ian Law Helle Broholm Line Madsen Christer Lundell-Ek Morten F. Gjerstorff Henrik J. Ditzel Martin R. Jensen Walter Fischer
author_sort	Alexei F. Kirkin
title	Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells
title_short	Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells
title_full	Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells
title_fullStr	Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells
title_full_unstemmed	Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells
title_sort	adoptive cancer immunotherapy using dna-demethylated t helper cells as antigen-presenting cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ef1dc53a886a4a839839ded99353ddc1
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Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

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