Oxidation of F-actin controls the terminal steps of cytokinesis

Oxidation of F-actin controls the terminal steps of cytokinesis

Cytokinetic abscission relies on the local constriction after cytoskeleton disassembly, but it is not known how the actin filaments are disassembled. Here, the authors show that the redox enzyme MICAL1 is recruited by Rab35 and induces oxidation-mediated depolymerization of actin, which is required...

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Autores principales: Stéphane Frémont, Hussein Hammich, Jian Bai, Hugo Wioland, Kerstin Klinkert, Murielle Rocancourt, Carlos Kikuti, David Stroebel, Guillaume Romet-Lemonne, Olena Pylypenko, Anne Houdusse, Arnaud Echard
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ef2347de83094d2db6126f7699dfdbc7
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spelling oai:doaj.org-article:ef2347de83094d2db6126f7699dfdbc72021-12-02T15:38:52ZOxidation of F-actin controls the terminal steps of cytokinesis10.1038/ncomms145282041-1723https://doaj.org/article/ef2347de83094d2db6126f7699dfdbc72017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14528https://doaj.org/toc/2041-1723Cytokinetic abscission relies on the local constriction after cytoskeleton disassembly, but it is not known how the actin filaments are disassembled. Here, the authors show that the redox enzyme MICAL1 is recruited by Rab35 and induces oxidation-mediated depolymerization of actin, which is required to recruit ESCRT-III and complete abscission.Stéphane FrémontHussein HammichJian BaiHugo WiolandKerstin KlinkertMurielle RocancourtCarlos KikutiDavid StroebelGuillaume Romet-LemonneOlena PylypenkoAnne HoudusseArnaud EchardNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Stéphane Frémont
Hussein Hammich
Jian Bai
Hugo Wioland
Kerstin Klinkert
Murielle Rocancourt
Carlos Kikuti
David Stroebel
Guillaume Romet-Lemonne
Olena Pylypenko
Anne Houdusse
Arnaud Echard
Oxidation of F-actin controls the terminal steps of cytokinesis
description Cytokinetic abscission relies on the local constriction after cytoskeleton disassembly, but it is not known how the actin filaments are disassembled. Here, the authors show that the redox enzyme MICAL1 is recruited by Rab35 and induces oxidation-mediated depolymerization of actin, which is required to recruit ESCRT-III and complete abscission.
format article
author Stéphane Frémont
Hussein Hammich
Jian Bai
Hugo Wioland
Kerstin Klinkert
Murielle Rocancourt
Carlos Kikuti
David Stroebel
Guillaume Romet-Lemonne
Olena Pylypenko
Anne Houdusse
Arnaud Echard
author_facet Stéphane Frémont
Hussein Hammich
Jian Bai
Hugo Wioland
Kerstin Klinkert
Murielle Rocancourt
Carlos Kikuti
David Stroebel
Guillaume Romet-Lemonne
Olena Pylypenko
Anne Houdusse
Arnaud Echard
author_sort Stéphane Frémont
title Oxidation of F-actin controls the terminal steps of cytokinesis
title_short Oxidation of F-actin controls the terminal steps of cytokinesis
title_full Oxidation of F-actin controls the terminal steps of cytokinesis
title_fullStr Oxidation of F-actin controls the terminal steps of cytokinesis
title_full_unstemmed Oxidation of F-actin controls the terminal steps of cytokinesis
title_sort oxidation of f-actin controls the terminal steps of cytokinesis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/ef2347de83094d2db6126f7699dfdbc7
work_keys_str_mv AT stephanefremont oxidationoffactincontrolstheterminalstepsofcytokinesis
AT husseinhammich oxidationoffactincontrolstheterminalstepsofcytokinesis
AT jianbai oxidationoffactincontrolstheterminalstepsofcytokinesis
AT hugowioland oxidationoffactincontrolstheterminalstepsofcytokinesis
AT kerstinklinkert oxidationoffactincontrolstheterminalstepsofcytokinesis
AT muriellerocancourt oxidationoffactincontrolstheterminalstepsofcytokinesis
AT carloskikuti oxidationoffactincontrolstheterminalstepsofcytokinesis
AT davidstroebel oxidationoffactincontrolstheterminalstepsofcytokinesis
AT guillaumerometlemonne oxidationoffactincontrolstheterminalstepsofcytokinesis
AT olenapylypenko oxidationoffactincontrolstheterminalstepsofcytokinesis
AT annehoudusse oxidationoffactincontrolstheterminalstepsofcytokinesis
AT arnaudechard oxidationoffactincontrolstheterminalstepsofcytokinesis
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