New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction

Abstract Chronic intestinal pseudo-obstruction (CIPO) is a severe and refractory intestinal motility disorder whose diagnosis currently relies on subjective imaging assessments. Cine magnetic resonance imaging (MRI) may potentially improve the quantitative analysis of gastrointestinal motility; howe...

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Autores principales:	Hiroki Sato, Hiroyuki Ogihara, Kazuya Takahashi, Yuzo Kawata, Yuichi Kojima, Kentaro Tominaga, Junji Yokoyama, Yoshihiko Hamamoto, Shuji Terai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef25ffa2c9734293ba0f8d7f97b4777a
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spelling	oai:doaj.org-article:ef25ffa2c9734293ba0f8d7f97b4777a2021-11-28T12:21:45ZNew cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction10.1038/s41598-021-02268-12045-2322https://doaj.org/article/ef25ffa2c9734293ba0f8d7f97b4777a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02268-1https://doaj.org/toc/2045-2322Abstract Chronic intestinal pseudo-obstruction (CIPO) is a severe and refractory intestinal motility disorder whose diagnosis currently relies on subjective imaging assessments. Cine magnetic resonance imaging (MRI) may potentially improve the quantitative analysis of gastrointestinal motility; however, suitable CIPO detection parameters should be determined. Cine MRI was performed in seven patients with CIPO and 11 healthy controls. The logarithm of the Mahalanobis distance (x1) and distance variation per time (x2) were used as the original parameters to determine CIPO diagnostic thresholds. Furthermore, the correlation between cine MRI findings and CIPO severity was investigated. Threshold values of α = 1.10 and β = 0.15 for x1 and x2, respectively, produced a CIPO diagnosis sensitivity of 1.00 (7/7) and specificity of 0.82 (9/11). The resulting error was 0.11 (2/18). The two parameters were correlated (Pearson’s correlation coefficient: − 0.52). Any of the intestinal tracts of patients with severe CIPO requiring home parenteral nutrition belonged to the region defined by x1 ≥ 1.10 and x2 ≤ 0.15. Cine MRI is effective for the quantitative evaluation of small intestinal motility and CIPO diagnosis when using the abovementioned parameters and can be useful for treatment decision-making. However, these parameters have a wide distribution in healthy volunteers; this may complicate the detection of other disorders.Hiroki SatoHiroyuki OgiharaKazuya TakahashiYuzo KawataYuichi KojimaKentaro TominagaJunji YokoyamaYoshihiko HamamotoShuji TeraiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroki Sato Hiroyuki Ogihara Kazuya Takahashi Yuzo Kawata Yuichi Kojima Kentaro Tominaga Junji Yokoyama Yoshihiko Hamamoto Shuji Terai New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction
description	Abstract Chronic intestinal pseudo-obstruction (CIPO) is a severe and refractory intestinal motility disorder whose diagnosis currently relies on subjective imaging assessments. Cine magnetic resonance imaging (MRI) may potentially improve the quantitative analysis of gastrointestinal motility; however, suitable CIPO detection parameters should be determined. Cine MRI was performed in seven patients with CIPO and 11 healthy controls. The logarithm of the Mahalanobis distance (x1) and distance variation per time (x2) were used as the original parameters to determine CIPO diagnostic thresholds. Furthermore, the correlation between cine MRI findings and CIPO severity was investigated. Threshold values of α = 1.10 and β = 0.15 for x1 and x2, respectively, produced a CIPO diagnosis sensitivity of 1.00 (7/7) and specificity of 0.82 (9/11). The resulting error was 0.11 (2/18). The two parameters were correlated (Pearson’s correlation coefficient: − 0.52). Any of the intestinal tracts of patients with severe CIPO requiring home parenteral nutrition belonged to the region defined by x1 ≥ 1.10 and x2 ≤ 0.15. Cine MRI is effective for the quantitative evaluation of small intestinal motility and CIPO diagnosis when using the abovementioned parameters and can be useful for treatment decision-making. However, these parameters have a wide distribution in healthy volunteers; this may complicate the detection of other disorders.
format	article
author	Hiroki Sato Hiroyuki Ogihara Kazuya Takahashi Yuzo Kawata Yuichi Kojima Kentaro Tominaga Junji Yokoyama Yoshihiko Hamamoto Shuji Terai
author_facet	Hiroki Sato Hiroyuki Ogihara Kazuya Takahashi Yuzo Kawata Yuichi Kojima Kentaro Tominaga Junji Yokoyama Yoshihiko Hamamoto Shuji Terai
author_sort	Hiroki Sato
title	New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction
title_short	New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction
title_full	New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction
title_fullStr	New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction
title_full_unstemmed	New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction
title_sort	new cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef25ffa2c9734293ba0f8d7f97b4777a
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New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction

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