Sub-Inhibitory Antibiotic Exposure and Virulence in <i>Pseudomonas aeruginosa</i>

<i>Pseudomonas aeruginosa</i> is a prime opportunistic pathogen, one of the most important causes of hospital-acquired infections and the major cause of morbidity and mortality in cystic fibrosis lung infections. One reason for the bacterium’s pathogenic success is the large array of vir...

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Autores principales:	Charlotte Nolan, Volker Behrends
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>P. aeruginosa</i> antibiotics cystic fibrosis metabolism virulence factors azithromycin Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ef263f498e2a445a9eb1b80b5e1e9750
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spelling	oai:doaj.org-article:ef263f498e2a445a9eb1b80b5e1e97502021-11-25T16:24:37ZSub-Inhibitory Antibiotic Exposure and Virulence in <i>Pseudomonas aeruginosa</i>10.3390/antibiotics101113932079-6382https://doaj.org/article/ef263f498e2a445a9eb1b80b5e1e97502021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1393https://doaj.org/toc/2079-6382<i>Pseudomonas aeruginosa</i> is a prime opportunistic pathogen, one of the most important causes of hospital-acquired infections and the major cause of morbidity and mortality in cystic fibrosis lung infections. One reason for the bacterium’s pathogenic success is the large array of virulence factors that it can employ. Another is its high degree of intrinsic and acquired resistance to antibiotics. In this review, we first summarise the current knowledge about the regulation of virulence factor expression and production. We then look at the impact of sub-MIC antibiotic exposure and find that the virulence–antibiotic interaction for <i>P. aeruginosa</i> is antibiotic-specific, multifaceted, and complex. Most studies undertaken to date have been <i>in vitro</i> assays in batch culture systems, involving short-term (<24 h) antibiotic exposure. Therefore, we discuss the importance of long-term, <i>in vivo-</i>mimicking models for future work, particularly highlighting the need to account for bacterial physiology, which by extension governs both virulence factor expression and antibiotic tolerance/resistance.Charlotte NolanVolker BehrendsMDPI AGarticle<i>P. aeruginosa</i>antibioticscystic fibrosismetabolismvirulence factorsazithromycinTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1393, p 1393 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>P. aeruginosa</i> antibiotics cystic fibrosis metabolism virulence factors azithromycin Therapeutics. Pharmacology RM1-950
spellingShingle	<i>P. aeruginosa</i> antibiotics cystic fibrosis metabolism virulence factors azithromycin Therapeutics. Pharmacology RM1-950 Charlotte Nolan Volker Behrends Sub-Inhibitory Antibiotic Exposure and Virulence in <i>Pseudomonas aeruginosa</i>
description	<i>Pseudomonas aeruginosa</i> is a prime opportunistic pathogen, one of the most important causes of hospital-acquired infections and the major cause of morbidity and mortality in cystic fibrosis lung infections. One reason for the bacterium’s pathogenic success is the large array of virulence factors that it can employ. Another is its high degree of intrinsic and acquired resistance to antibiotics. In this review, we first summarise the current knowledge about the regulation of virulence factor expression and production. We then look at the impact of sub-MIC antibiotic exposure and find that the virulence–antibiotic interaction for <i>P. aeruginosa</i> is antibiotic-specific, multifaceted, and complex. Most studies undertaken to date have been <i>in vitro</i> assays in batch culture systems, involving short-term (<24 h) antibiotic exposure. Therefore, we discuss the importance of long-term, <i>in vivo-</i>mimicking models for future work, particularly highlighting the need to account for bacterial physiology, which by extension governs both virulence factor expression and antibiotic tolerance/resistance.
format	article
author	Charlotte Nolan Volker Behrends
author_facet	Charlotte Nolan Volker Behrends
author_sort	Charlotte Nolan
title	Sub-Inhibitory Antibiotic Exposure and Virulence in <i>Pseudomonas aeruginosa</i>
title_short	Sub-Inhibitory Antibiotic Exposure and Virulence in <i>Pseudomonas aeruginosa</i>
title_full	Sub-Inhibitory Antibiotic Exposure and Virulence in <i>Pseudomonas aeruginosa</i>
title_fullStr	Sub-Inhibitory Antibiotic Exposure and Virulence in <i>Pseudomonas aeruginosa</i>
title_full_unstemmed	Sub-Inhibitory Antibiotic Exposure and Virulence in <i>Pseudomonas aeruginosa</i>
title_sort	sub-inhibitory antibiotic exposure and virulence in <i>pseudomonas aeruginosa</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ef263f498e2a445a9eb1b80b5e1e9750
work_keys_str_mv	AT charlottenolan subinhibitoryantibioticexposureandvirulenceinipseudomonasaeruginosai AT volkerbehrends subinhibitoryantibioticexposureandvirulenceinipseudomonasaeruginosai
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Sub-Inhibitory Antibiotic Exposure and Virulence in <i>Pseudomonas aeruginosa</i>

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