Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs

Hasan and Berdichevsky report the use of 3D neuronal-astrocyte co-cultures in PDMS confinement to enable the study of aggregation, migration, contractility, and sorting of these cells. They show that aggregation is a neuron mediated process, and formation of astrocyte-rich sheaths in 3D cultures dep...

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Autores principales:	Md Fayad Hasan, Yevgeny Berdichevsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ef265822eb3c480c80bcf60ccfeda228
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spelling	oai:doaj.org-article:ef265822eb3c480c80bcf60ccfeda2282021-12-02T14:58:32ZNeuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs10.1038/s42003-021-02104-22399-3642https://doaj.org/article/ef265822eb3c480c80bcf60ccfeda2282021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02104-2https://doaj.org/toc/2399-3642Hasan and Berdichevsky report the use of 3D neuronal-astrocyte co-cultures in PDMS confinement to enable the study of aggregation, migration, contractility, and sorting of these cells. They show that aggregation is a neuron mediated process, and formation of astrocyte-rich sheaths in 3D cultures depends on differential attraction between neurons and astrocytes, highlighting the use of this model in future design of neuronal constructs.Md Fayad HasanYevgeny BerdichevskyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Md Fayad Hasan Yevgeny Berdichevsky Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
description	Hasan and Berdichevsky report the use of 3D neuronal-astrocyte co-cultures in PDMS confinement to enable the study of aggregation, migration, contractility, and sorting of these cells. They show that aggregation is a neuron mediated process, and formation of astrocyte-rich sheaths in 3D cultures depends on differential attraction between neurons and astrocytes, highlighting the use of this model in future design of neuronal constructs.
format	article
author	Md Fayad Hasan Yevgeny Berdichevsky
author_facet	Md Fayad Hasan Yevgeny Berdichevsky
author_sort	Md Fayad Hasan
title	Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
title_short	Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
title_full	Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
title_fullStr	Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
title_full_unstemmed	Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
title_sort	neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef265822eb3c480c80bcf60ccfeda228
work_keys_str_mv	AT mdfayadhasan neuronandastrocyteaggregationandsortinginthreedimensionalneuronalconstructs AT yevgenyberdichevsky neuronandastrocyteaggregationandsortinginthreedimensionalneuronalconstructs
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Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs

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