Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate agin...

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Autores principales:	Liping Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang, Pedro Guillen, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, Guang-Hui Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef27753ea31d478c8881938090f2b42a
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spelling	oai:doaj.org-article:ef27753ea31d478c8881938090f2b42a2021-12-02T15:35:18ZStabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis10.1038/s41467-019-10831-82041-1723https://doaj.org/article/ef27753ea31d478c8881938090f2b42a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10831-8https://doaj.org/toc/2041-1723DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate aging and senescenceLiping DengRuotong RenZunpeng LiuMoshi SongJingyi LiZeming WuXiaoqing RenLina FuWei LiWeiqi ZhangPedro GuillenJuan Carlos Izpisua BelmontePiu ChanJing QuGuang-Hui LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liping Deng Ruotong Ren Zunpeng Liu Moshi Song Jingyi Li Zeming Wu Xiaoqing Ren Lina Fu Wei Li Weiqi Zhang Pedro Guillen Juan Carlos Izpisua Belmonte Piu Chan Jing Qu Guang-Hui Liu Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
description	DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate aging and senescence
format	article
author	Liping Deng Ruotong Ren Zunpeng Liu Moshi Song Jingyi Li Zeming Wu Xiaoqing Ren Lina Fu Wei Li Weiqi Zhang Pedro Guillen Juan Carlos Izpisua Belmonte Piu Chan Jing Qu Guang-Hui Liu
author_facet	Liping Deng Ruotong Ren Zunpeng Liu Moshi Song Jingyi Li Zeming Wu Xiaoqing Ren Lina Fu Wei Li Weiqi Zhang Pedro Guillen Juan Carlos Izpisua Belmonte Piu Chan Jing Qu Guang-Hui Liu
author_sort	Liping Deng
title	Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_short	Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_full	Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_fullStr	Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_full_unstemmed	Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_sort	stabilizing heterochromatin by dgcr8 alleviates senescence and osteoarthritis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ef27753ea31d478c8881938090f2b42a
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Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

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