Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate agin...

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Autores principales: Liping Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang, Pedro Guillen, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, Guang-Hui Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/ef27753ea31d478c8881938090f2b42a
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