Genomic instability in mutant p53 cancer cells upon entotic engulfment

Cell-in-cell (CIC) structures are frequently observed in cancers; however, it is unclear how their formation contributes to tumorigenesis. Here, the authors show that the high frequency of CIC is linked to mutant p53 status and CIC containing p53 mutant cancer cells are pro-tumorigenic due to enhanc...

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Autores principales:	Hannah L. Mackay, David Moore, Callum Hall, Nicolai J. Birkbak, Mariam Jamal-Hanjani, Saadia A. Karim, Vinaya M. Phatak, Lucia Piñon, Jennifer P. Morton, Charles Swanton, John Le Quesne, Patricia A. J. Muller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef2a3a3e5000438daad1f6418bdb7058
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spelling	oai:doaj.org-article:ef2a3a3e5000438daad1f6418bdb70582021-12-02T17:32:14ZGenomic instability in mutant p53 cancer cells upon entotic engulfment10.1038/s41467-018-05368-12041-1723https://doaj.org/article/ef2a3a3e5000438daad1f6418bdb70582018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05368-1https://doaj.org/toc/2041-1723Cell-in-cell (CIC) structures are frequently observed in cancers; however, it is unclear how their formation contributes to tumorigenesis. Here, the authors show that the high frequency of CIC is linked to mutant p53 status and CIC containing p53 mutant cancer cells are pro-tumorigenic due to enhanced genomic instability.Hannah L. MackayDavid MooreCallum HallNicolai J. BirkbakMariam Jamal-HanjaniSaadia A. KarimVinaya M. PhatakLucia PiñonJennifer P. MortonCharles SwantonJohn Le QuesnePatricia A. J. MullerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hannah L. Mackay David Moore Callum Hall Nicolai J. Birkbak Mariam Jamal-Hanjani Saadia A. Karim Vinaya M. Phatak Lucia Piñon Jennifer P. Morton Charles Swanton John Le Quesne Patricia A. J. Muller Genomic instability in mutant p53 cancer cells upon entotic engulfment
description	Cell-in-cell (CIC) structures are frequently observed in cancers; however, it is unclear how their formation contributes to tumorigenesis. Here, the authors show that the high frequency of CIC is linked to mutant p53 status and CIC containing p53 mutant cancer cells are pro-tumorigenic due to enhanced genomic instability.
format	article
author	Hannah L. Mackay David Moore Callum Hall Nicolai J. Birkbak Mariam Jamal-Hanjani Saadia A. Karim Vinaya M. Phatak Lucia Piñon Jennifer P. Morton Charles Swanton John Le Quesne Patricia A. J. Muller
author_facet	Hannah L. Mackay David Moore Callum Hall Nicolai J. Birkbak Mariam Jamal-Hanjani Saadia A. Karim Vinaya M. Phatak Lucia Piñon Jennifer P. Morton Charles Swanton John Le Quesne Patricia A. J. Muller
author_sort	Hannah L. Mackay
title	Genomic instability in mutant p53 cancer cells upon entotic engulfment
title_short	Genomic instability in mutant p53 cancer cells upon entotic engulfment
title_full	Genomic instability in mutant p53 cancer cells upon entotic engulfment
title_fullStr	Genomic instability in mutant p53 cancer cells upon entotic engulfment
title_full_unstemmed	Genomic instability in mutant p53 cancer cells upon entotic engulfment
title_sort	genomic instability in mutant p53 cancer cells upon entotic engulfment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ef2a3a3e5000438daad1f6418bdb7058
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Genomic instability in mutant p53 cancer cells upon entotic engulfment

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