ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects

Huntington’s disease leads to mitochondrial fragmentation and bioenergetic failure, although how the two events are connected is poorly understood. Here, Zhao et al. identify ATAD3A as a molecular linker and show that a peptide inhibitor of ATAD3A oligomerization suppresses HD phenotypes.

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Autores principales:	Yuanyuan Zhao, Xiaoyan Sun, Di Hu, Domenick A. Prosdocimo, Charles Hoppel, Mukesh K. Jain, Rajesh Ramachandran, Xin Qi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef3003cefae44cb3a8b90c02b9d5b647
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spelling	oai:doaj.org-article:ef3003cefae44cb3a8b90c02b9d5b6472021-12-02T14:35:37ZATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects10.1038/s41467-019-09291-x2041-1723https://doaj.org/article/ef3003cefae44cb3a8b90c02b9d5b6472019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09291-xhttps://doaj.org/toc/2041-1723Huntington’s disease leads to mitochondrial fragmentation and bioenergetic failure, although how the two events are connected is poorly understood. Here, Zhao et al. identify ATAD3A as a molecular linker and show that a peptide inhibitor of ATAD3A oligomerization suppresses HD phenotypes.Yuanyuan ZhaoXiaoyan SunDi HuDomenick A. ProsdocimoCharles HoppelMukesh K. JainRajesh RamachandranXin QiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuanyuan Zhao Xiaoyan Sun Di Hu Domenick A. Prosdocimo Charles Hoppel Mukesh K. Jain Rajesh Ramachandran Xin Qi ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
description	Huntington’s disease leads to mitochondrial fragmentation and bioenergetic failure, although how the two events are connected is poorly understood. Here, Zhao et al. identify ATAD3A as a molecular linker and show that a peptide inhibitor of ATAD3A oligomerization suppresses HD phenotypes.
format	article
author	Yuanyuan Zhao Xiaoyan Sun Di Hu Domenick A. Prosdocimo Charles Hoppel Mukesh K. Jain Rajesh Ramachandran Xin Qi
author_facet	Yuanyuan Zhao Xiaoyan Sun Di Hu Domenick A. Prosdocimo Charles Hoppel Mukesh K. Jain Rajesh Ramachandran Xin Qi
author_sort	Yuanyuan Zhao
title	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
title_short	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
title_full	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
title_fullStr	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
title_full_unstemmed	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
title_sort	atad3a oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ef3003cefae44cb3a8b90c02b9d5b647
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ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects

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