ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects

Huntington’s disease leads to mitochondrial fragmentation and bioenergetic failure, although how the two events are connected is poorly understood. Here, Zhao et al. identify ATAD3A as a molecular linker and show that a peptide inhibitor of ATAD3A oligomerization suppresses HD phenotypes.

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Autores principales: Yuanyuan Zhao, Xiaoyan Sun, Di Hu, Domenick A. Prosdocimo, Charles Hoppel, Mukesh K. Jain, Rajesh Ramachandran, Xin Qi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ef3003cefae44cb3a8b90c02b9d5b647
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