Neutrophil/Lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.

<h4>Background</h4>Elevations in soluble markers of inflammation and changes in leukocyte subset distribution are frequently reported in patients with coronary artery disease (CAD). Lately, the neutrophil/lymphocyte ratio has emerged as a potential marker of both CAD severity and cardiov...

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Autores principales:	Lennart Nilsson, Wouter G Wieringa, Gabija Pundziute, Marcus Gjerde, Jan Engvall, Eva Swahn, Lena Jonasson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef3023566f204f21a60dfedf28cfac3b
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spelling	oai:doaj.org-article:ef3023566f204f21a60dfedf28cfac3b2021-11-25T05:58:38ZNeutrophil/Lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.1932-620310.1371/journal.pone.0108183https://doaj.org/article/ef3023566f204f21a60dfedf28cfac3b2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0108183https://doaj.org/toc/1932-6203<h4>Background</h4>Elevations in soluble markers of inflammation and changes in leukocyte subset distribution are frequently reported in patients with coronary artery disease (CAD). Lately, the neutrophil/lymphocyte ratio has emerged as a potential marker of both CAD severity and cardiovascular prognosis.<h4>Objectives</h4>The aim of the study was to investigate whether neutrophil/lymphocyte ratio and other immune-inflammatory markers were related to plaque burden, as assessed by coronary computed tomography angiography (CCTA), in patients with CAD.<h4>Methods</h4>Twenty patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) and 30 patients with stable angina (SA) underwent CCTA at two occasions, immediately prior to coronary angiography and after three months. Atherosclerotic plaques were classified as calcified, mixed and non-calcified. Blood samples were drawn at both occasions. Leukocyte subsets were analyzed by white blood cell differential counts and flow cytometry. Levels of C-reactive protein (CRP) and interleukin(IL)-6 were measured in plasma. Blood analyses were also performed in 37 healthy controls.<h4>Results</h4>Plaque variables did not change over 3 months, total plaque burden being similar in NSTE-ACS and SA. However, non-calcified/total plaque ratio was higher in NSTE-ACS, 0.25(0.09-0.44) vs 0.11(0.00-0.25), p<0.05. At admission, levels of monocytes, neutrophils, neutrophil/lymphocyte ratios, CD4+ T cells, CRP and IL-6 were significantly elevated, while levels of NK cells were reduced, in both patient groups as compared to controls. After 3 months, levels of monocytes, neutrophils, neutrophil/lymphocyte ratios and CD4+ T cells remained elevated in patients. Neutrophil/lymphocyte ratios and neutrophil counts correlated significantly with numbers of non-calcified plaques and also with non-calcified/total plaque ratio (r = 0.403, p = 0.010 and r = 0.382, p = 0.024, respectively), but not with total plaque burden.<h4>Conclusions</h4>Among immune-inflammatory markers in NSTE-ACS and SA patients, neutrophil counts and neutrophil/lymphocyte ratios were significantly correlated with non-calcified plaques. Data suggest that these easily measured biomarkers reflect the burden of vulnerable plaques in CAD.Lennart NilssonWouter G WieringaGabija PundziuteMarcus GjerdeJan EngvallEva SwahnLena JonassonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e108183 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lennart Nilsson Wouter G Wieringa Gabija Pundziute Marcus Gjerde Jan Engvall Eva Swahn Lena Jonasson Neutrophil/Lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.
description	<h4>Background</h4>Elevations in soluble markers of inflammation and changes in leukocyte subset distribution are frequently reported in patients with coronary artery disease (CAD). Lately, the neutrophil/lymphocyte ratio has emerged as a potential marker of both CAD severity and cardiovascular prognosis.<h4>Objectives</h4>The aim of the study was to investigate whether neutrophil/lymphocyte ratio and other immune-inflammatory markers were related to plaque burden, as assessed by coronary computed tomography angiography (CCTA), in patients with CAD.<h4>Methods</h4>Twenty patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) and 30 patients with stable angina (SA) underwent CCTA at two occasions, immediately prior to coronary angiography and after three months. Atherosclerotic plaques were classified as calcified, mixed and non-calcified. Blood samples were drawn at both occasions. Leukocyte subsets were analyzed by white blood cell differential counts and flow cytometry. Levels of C-reactive protein (CRP) and interleukin(IL)-6 were measured in plasma. Blood analyses were also performed in 37 healthy controls.<h4>Results</h4>Plaque variables did not change over 3 months, total plaque burden being similar in NSTE-ACS and SA. However, non-calcified/total plaque ratio was higher in NSTE-ACS, 0.25(0.09-0.44) vs 0.11(0.00-0.25), p<0.05. At admission, levels of monocytes, neutrophils, neutrophil/lymphocyte ratios, CD4+ T cells, CRP and IL-6 were significantly elevated, while levels of NK cells were reduced, in both patient groups as compared to controls. After 3 months, levels of monocytes, neutrophils, neutrophil/lymphocyte ratios and CD4+ T cells remained elevated in patients. Neutrophil/lymphocyte ratios and neutrophil counts correlated significantly with numbers of non-calcified plaques and also with non-calcified/total plaque ratio (r = 0.403, p = 0.010 and r = 0.382, p = 0.024, respectively), but not with total plaque burden.<h4>Conclusions</h4>Among immune-inflammatory markers in NSTE-ACS and SA patients, neutrophil counts and neutrophil/lymphocyte ratios were significantly correlated with non-calcified plaques. Data suggest that these easily measured biomarkers reflect the burden of vulnerable plaques in CAD.
format	article
author	Lennart Nilsson Wouter G Wieringa Gabija Pundziute Marcus Gjerde Jan Engvall Eva Swahn Lena Jonasson
author_facet	Lennart Nilsson Wouter G Wieringa Gabija Pundziute Marcus Gjerde Jan Engvall Eva Swahn Lena Jonasson
author_sort	Lennart Nilsson
title	Neutrophil/Lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.
title_short	Neutrophil/Lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.
title_full	Neutrophil/Lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.
title_fullStr	Neutrophil/Lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.
title_full_unstemmed	Neutrophil/Lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.
title_sort	neutrophil/lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/ef3023566f204f21a60dfedf28cfac3b
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Neutrophil/Lymphocyte ratio is associated with non-calcified plaque burden in patients with coronary artery disease.

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