Computational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma

Long non-coding RNAs (lncRNAs), which were implicated in many pathophysiological processes including cancer, were frequently dysregulated in hepatocellular carcinoma (HCC). Studies have demonstrated that ferroptosis and immunity can regulate the biological behaviors of tumors. Therefore, biomarkers...

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Autores principales:	Anmin Huang, Ting Li, Xueting Xie, Jinglin Xia
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ferroptosis immune long non-coding RNA (lncRNA) hepatocellular carcinoma prognosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ef36d98060f84f3c8620769807714357
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spelling	oai:doaj.org-article:ef36d98060f84f3c86207698077143572021-12-01T01:20:20ZComputational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma2296-889X10.3389/fmolb.2021.759173https://doaj.org/article/ef36d98060f84f3c86207698077143572021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.759173/fullhttps://doaj.org/toc/2296-889XLong non-coding RNAs (lncRNAs), which were implicated in many pathophysiological processes including cancer, were frequently dysregulated in hepatocellular carcinoma (HCC). Studies have demonstrated that ferroptosis and immunity can regulate the biological behaviors of tumors. Therefore, biomarkers that combined ferroptosis, immunity, and lncRNA can be a promising candidate bioindicator in clinical therapy of cancers. Many bioinformatics methods, including Pearson correlation analysis, univariate Cox proportional hazard regression analysis, least absolute shrinkage and selection operator (LASSO) analysis, and multivariate Cox proportional hazard regression analysis were applied to develop a prognostic risk signature of immune- and ferroptosis-related lncRNA (IFLSig). Finally, eight immune- and ferroptosis-related lncRNAs (IFLncRNA) were identified to develop and IFLSig of HCC patients. We found the prognosis of patients with high IFLSig will be worse, while the prognosis of patients with low IFLSig will be better. The results provide an efficient method of uniting critical clinical information with immunological characteristics, enabling estimation of the overall survival (OS). Such an integrative prognostic model with high predictive power would have a notable impact and utility in prognosis prediction and individualized treatment strategies.Anmin HuangAnmin HuangTing LiXueting XieJinglin XiaJinglin XiaFrontiers Media S.A.articleferroptosisimmunelong non-coding RNA (lncRNA)hepatocellular carcinomaprognosisBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferroptosis immune long non-coding RNA (lncRNA) hepatocellular carcinoma prognosis Biology (General) QH301-705.5
spellingShingle	ferroptosis immune long non-coding RNA (lncRNA) hepatocellular carcinoma prognosis Biology (General) QH301-705.5 Anmin Huang Anmin Huang Ting Li Xueting Xie Jinglin Xia Jinglin Xia Computational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma
description	Long non-coding RNAs (lncRNAs), which were implicated in many pathophysiological processes including cancer, were frequently dysregulated in hepatocellular carcinoma (HCC). Studies have demonstrated that ferroptosis and immunity can regulate the biological behaviors of tumors. Therefore, biomarkers that combined ferroptosis, immunity, and lncRNA can be a promising candidate bioindicator in clinical therapy of cancers. Many bioinformatics methods, including Pearson correlation analysis, univariate Cox proportional hazard regression analysis, least absolute shrinkage and selection operator (LASSO) analysis, and multivariate Cox proportional hazard regression analysis were applied to develop a prognostic risk signature of immune- and ferroptosis-related lncRNA (IFLSig). Finally, eight immune- and ferroptosis-related lncRNAs (IFLncRNA) were identified to develop and IFLSig of HCC patients. We found the prognosis of patients with high IFLSig will be worse, while the prognosis of patients with low IFLSig will be better. The results provide an efficient method of uniting critical clinical information with immunological characteristics, enabling estimation of the overall survival (OS). Such an integrative prognostic model with high predictive power would have a notable impact and utility in prognosis prediction and individualized treatment strategies.
format	article
author	Anmin Huang Anmin Huang Ting Li Xueting Xie Jinglin Xia Jinglin Xia
author_facet	Anmin Huang Anmin Huang Ting Li Xueting Xie Jinglin Xia Jinglin Xia
author_sort	Anmin Huang
title	Computational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma
title_short	Computational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma
title_full	Computational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma
title_fullStr	Computational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma
title_full_unstemmed	Computational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma
title_sort	computational identification of immune- and ferroptosis-related lncrna signature for prognosis of hepatocellular carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ef36d98060f84f3c8620769807714357
work_keys_str_mv	AT anminhuang computationalidentificationofimmuneandferroptosisrelatedlncrnasignatureforprognosisofhepatocellularcarcinoma AT anminhuang computationalidentificationofimmuneandferroptosisrelatedlncrnasignatureforprognosisofhepatocellularcarcinoma AT tingli computationalidentificationofimmuneandferroptosisrelatedlncrnasignatureforprognosisofhepatocellularcarcinoma AT xuetingxie computationalidentificationofimmuneandferroptosisrelatedlncrnasignatureforprognosisofhepatocellularcarcinoma AT jinglinxia computationalidentificationofimmuneandferroptosisrelatedlncrnasignatureforprognosisofhepatocellularcarcinoma AT jinglinxia computationalidentificationofimmuneandferroptosisrelatedlncrnasignatureforprognosisofhepatocellularcarcinoma
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Computational Identification of Immune- and Ferroptosis-Related LncRNA Signature for Prognosis of Hepatocellular Carcinoma

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