RELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA

Abstract. It was found that development of lipid disorders in rats is accompanied by increased levels of tumor necrosis factor alpha (TNFα) in blood and liver, decreased cytokine regulation index, thus suggesting arising inflammatory reaction at the organ and systemic levels...

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Autores principales:	E. G. Lobanova, Yu. K. Karaman
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	blood lipids tumor necrosis factor alimentary dyslipidemia correlation analysis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ef382870a7f84adf96734b4ccac0437f
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spelling	oai:doaj.org-article:ef382870a7f84adf96734b4ccac0437f2021-11-18T08:03:41ZRELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA1563-06252313-741X10.15789/1563-0625-2011-1-61-66https://doaj.org/article/ef382870a7f84adf96734b4ccac0437f2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/398https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. It was found that development of lipid disorders in rats is accompanied by increased levels of tumor necrosis factor alpha (TNFα) in blood and liver, decreased cytokine regulation index, thus suggesting arising inflammatory reaction at the organ and systemic levels, exhaustion of functional reserve and diminished response of immunocompetent cells. Intensity of TNFα secretion depends on the duration of emerging alimentary dyslipidemia in rats, i.e., maximal amounts of TNFα in blood and liver were detected at day 30 of evolving dyslipidemia. At 90th and 180th day after starting the alimentary load, a gradual inhibition of cytokineproducing ability by immune cells is observed. In the course of evolving alimentary dyslipidemia, the patterns of intra-and intersystemic interactions are altered towards increased correlations between lipid transport and immune markers, as well as higher intercorrelations between the parameters of blood lipid metabolism and proinflammatory cytokine levels in the liver. (Med. Immunol., 2011, vol. 13, N 1, pp 61-66)E. G. LobanovaYu. K. KaramanSPb RAACIarticleblood lipidstumor necrosis factoralimentary dyslipidemiacorrelation analysisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 61-66 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	blood lipids tumor necrosis factor alimentary dyslipidemia correlation analysis Immunologic diseases. Allergy RC581-607
spellingShingle	blood lipids tumor necrosis factor alimentary dyslipidemia correlation analysis Immunologic diseases. Allergy RC581-607 E. G. Lobanova Yu. K. Karaman RELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA
description	Abstract. It was found that development of lipid disorders in rats is accompanied by increased levels of tumor necrosis factor alpha (TNFα) in blood and liver, decreased cytokine regulation index, thus suggesting arising inflammatory reaction at the organ and systemic levels, exhaustion of functional reserve and diminished response of immunocompetent cells. Intensity of TNFα secretion depends on the duration of emerging alimentary dyslipidemia in rats, i.e., maximal amounts of TNFα in blood and liver were detected at day 30 of evolving dyslipidemia. At 90th and 180th day after starting the alimentary load, a gradual inhibition of cytokineproducing ability by immune cells is observed. In the course of evolving alimentary dyslipidemia, the patterns of intra-and intersystemic interactions are altered towards increased correlations between lipid transport and immune markers, as well as higher intercorrelations between the parameters of blood lipid metabolism and proinflammatory cytokine levels in the liver. (Med. Immunol., 2011, vol. 13, N 1, pp 61-66)
format	article
author	E. G. Lobanova Yu. K. Karaman
author_facet	E. G. Lobanova Yu. K. Karaman
author_sort	E. G. Lobanova
title	RELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA
title_short	RELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA
title_full	RELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA
title_fullStr	RELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA
title_full_unstemmed	RELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA
title_sort	relationships between lipid and immune disorders at various stages of developing experimental dyslipidemia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ef382870a7f84adf96734b4ccac0437f
work_keys_str_mv	AT eglobanova relationshipsbetweenlipidandimmunedisordersatvariousstagesofdevelopingexperimentaldyslipidemia AT yukkaraman relationshipsbetweenlipidandimmunedisordersatvariousstagesofdevelopingexperimentaldyslipidemia
_version_	1718422516731478016

RELATIONSHIPS BETWEEN LIPID AND IMMUNE DISORDERS AT VARIOUS STAGES OF DEVELOPING EXPERIMENTAL DYSLIPIDEMIA

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