Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.

Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.

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<h4>Background</h4>The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation.<h4>Methods</h4>We systematically searched electronic databases to identify articles reporting the i...

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Autores principales: Yukinori Takenaka, Norihiko Takemoto, Ryohei Oya, Hidenori Inohara
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/ef38580d3b074966be8808f9d64def6e
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spelling oai:doaj.org-article:ef38580d3b074966be8808f9d64def6e2021-12-02T20:13:19ZPrognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.1932-620310.1371/journal.pone.0259288https://doaj.org/article/ef38580d3b074966be8808f9d64def6e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259288https://doaj.org/toc/1932-6203<h4>Background</h4>The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation.<h4>Methods</h4>We systematically searched electronic databases to identify articles reporting the impact of sarcopenia on the prognosis of patients with HNC. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) were extracted and pooled. HR according to treatment modality were estimated using random-effects models. Statistical analyses were carried out using the Comprehensive Meta-Analysis software.<h4>Results</h4>In total, 18 studies enrolling 3,233 patients were included. Sarcopenia was associated with poor OS in both surgery and radiotherapy groups (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.95-3.21; HR 1.63, 95% CI 1.40-1.90, respectively). The HR was significantly higher in the surgery group than in the radiotherapy group (p = 0.004), with similar results obtained for DFS (HR 2.59, 95% CI 1.56-4.31; HR 1.56, 95% CI 1.24-1.97 for the surgery and radiotherapy groups, respectively) and DSS (HR 2.96, 95% CI 0.73-11.95; HR 2.67, 95% CI 1.51-4.73 for the surgery and RT groups, respectively).<h4>Conclusions</h4>Sarcopenia was a poor prognostic factor for HNC, regardless of the treatment modality. However, the adverse effects of sarcopenia on survival were more prominent in the surgery group than in the radiotherapy group. Sarcopenia assessment is required for appropriate treatment decision-making.Yukinori TakenakaNorihiko TakemotoRyohei OyaHidenori InoharaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0259288 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yukinori Takenaka
Norihiko Takemoto
Ryohei Oya
Hidenori Inohara
Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.
description <h4>Background</h4>The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation.<h4>Methods</h4>We systematically searched electronic databases to identify articles reporting the impact of sarcopenia on the prognosis of patients with HNC. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) were extracted and pooled. HR according to treatment modality were estimated using random-effects models. Statistical analyses were carried out using the Comprehensive Meta-Analysis software.<h4>Results</h4>In total, 18 studies enrolling 3,233 patients were included. Sarcopenia was associated with poor OS in both surgery and radiotherapy groups (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.95-3.21; HR 1.63, 95% CI 1.40-1.90, respectively). The HR was significantly higher in the surgery group than in the radiotherapy group (p = 0.004), with similar results obtained for DFS (HR 2.59, 95% CI 1.56-4.31; HR 1.56, 95% CI 1.24-1.97 for the surgery and radiotherapy groups, respectively) and DSS (HR 2.96, 95% CI 0.73-11.95; HR 2.67, 95% CI 1.51-4.73 for the surgery and RT groups, respectively).<h4>Conclusions</h4>Sarcopenia was a poor prognostic factor for HNC, regardless of the treatment modality. However, the adverse effects of sarcopenia on survival were more prominent in the surgery group than in the radiotherapy group. Sarcopenia assessment is required for appropriate treatment decision-making.
format article
author Yukinori Takenaka
Norihiko Takemoto
Ryohei Oya
Hidenori Inohara
author_facet Yukinori Takenaka
Norihiko Takemoto
Ryohei Oya
Hidenori Inohara
author_sort Yukinori Takenaka
title Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.
title_short Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.
title_full Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.
title_fullStr Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.
title_full_unstemmed Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis.
title_sort prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: a meta-analysis.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/ef38580d3b074966be8808f9d64def6e
work_keys_str_mv AT yukinoritakenaka prognosticimpactofsarcopeniainpatientswithheadandneckcancertreatedwithsurgeryorradiationametaanalysis
AT norihikotakemoto prognosticimpactofsarcopeniainpatientswithheadandneckcancertreatedwithsurgeryorradiationametaanalysis
AT ryoheioya prognosticimpactofsarcopeniainpatientswithheadandneckcancertreatedwithsurgeryorradiationametaanalysis
AT hidenoriinohara prognosticimpactofsarcopeniainpatientswithheadandneckcancertreatedwithsurgeryorradiationametaanalysis
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