ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and may play a role in cell migration.

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Autores principales: Gururaj Rao Kidiyoor, Qingsen Li, Giulia Bastianello, Christopher Bruhn, Irene Giovannetti, Adhil Mohamood, Galina V. Beznoussenko, Alexandre Mironov, Matthew Raab, Matthieu Piel, Umberto Restuccia, Vittoria Matafora, Angela Bachi, Sara Barozzi, Dario Parazzoli, Emanuela Frittoli, Andrea Palamidessi, Tito Panciera, Stefano Piccolo, Giorgio Scita, Paolo Maiuri, Kristina M. Havas, Zhong-Wei Zhou, Amit Kumar, Jiri Bartek, Zhao-Qi Wang, Marco Foiani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ef3b7523ea5c4ef99f9147b73d2702d2
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spelling oai:doaj.org-article:ef3b7523ea5c4ef99f9147b73d2702d22021-12-02T18:14:31ZATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration10.1038/s41467-020-18580-92041-1723https://doaj.org/article/ef3b7523ea5c4ef99f9147b73d2702d22020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18580-9https://doaj.org/toc/2041-1723The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and may play a role in cell migration.Gururaj Rao KidiyoorQingsen LiGiulia BastianelloChristopher BruhnIrene GiovannettiAdhil MohamoodGalina V. BeznoussenkoAlexandre MironovMatthew RaabMatthieu PielUmberto RestucciaVittoria MataforaAngela BachiSara BarozziDario ParazzoliEmanuela FrittoliAndrea PalamidessiTito PancieraStefano PiccoloGiorgio ScitaPaolo MaiuriKristina M. HavasZhong-Wei ZhouAmit KumarJiri BartekZhao-Qi WangMarco FoianiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gururaj Rao Kidiyoor
Qingsen Li
Giulia Bastianello
Christopher Bruhn
Irene Giovannetti
Adhil Mohamood
Galina V. Beznoussenko
Alexandre Mironov
Matthew Raab
Matthieu Piel
Umberto Restuccia
Vittoria Matafora
Angela Bachi
Sara Barozzi
Dario Parazzoli
Emanuela Frittoli
Andrea Palamidessi
Tito Panciera
Stefano Piccolo
Giorgio Scita
Paolo Maiuri
Kristina M. Havas
Zhong-Wei Zhou
Amit Kumar
Jiri Bartek
Zhao-Qi Wang
Marco Foiani
ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
description The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and may play a role in cell migration.
format article
author Gururaj Rao Kidiyoor
Qingsen Li
Giulia Bastianello
Christopher Bruhn
Irene Giovannetti
Adhil Mohamood
Galina V. Beznoussenko
Alexandre Mironov
Matthew Raab
Matthieu Piel
Umberto Restuccia
Vittoria Matafora
Angela Bachi
Sara Barozzi
Dario Parazzoli
Emanuela Frittoli
Andrea Palamidessi
Tito Panciera
Stefano Piccolo
Giorgio Scita
Paolo Maiuri
Kristina M. Havas
Zhong-Wei Zhou
Amit Kumar
Jiri Bartek
Zhao-Qi Wang
Marco Foiani
author_facet Gururaj Rao Kidiyoor
Qingsen Li
Giulia Bastianello
Christopher Bruhn
Irene Giovannetti
Adhil Mohamood
Galina V. Beznoussenko
Alexandre Mironov
Matthew Raab
Matthieu Piel
Umberto Restuccia
Vittoria Matafora
Angela Bachi
Sara Barozzi
Dario Parazzoli
Emanuela Frittoli
Andrea Palamidessi
Tito Panciera
Stefano Piccolo
Giorgio Scita
Paolo Maiuri
Kristina M. Havas
Zhong-Wei Zhou
Amit Kumar
Jiri Bartek
Zhao-Qi Wang
Marco Foiani
author_sort Gururaj Rao Kidiyoor
title ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
title_short ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
title_full ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
title_fullStr ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
title_full_unstemmed ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
title_sort atr is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ef3b7523ea5c4ef99f9147b73d2702d2
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