Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state

CD4+ T cells contain a T-bethigh memory-phenotype (MP) population with innate-like functions. Here the authors characterize the requirements for their differentiation at homeostasis and identify a function for IL-12 that is tonically produced by type 1 dendritic cells in an MyD88- and CD40-dependent...

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Autores principales:	Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef3cb49a011444f1ac9d73d4ce336452
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spelling	oai:doaj.org-article:ef3cb49a011444f1ac9d73d4ce3364522021-12-02T18:34:21ZRequirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state10.1038/s41467-020-17136-12041-1723https://doaj.org/article/ef3cb49a011444f1ac9d73d4ce3364522020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17136-1https://doaj.org/toc/2041-1723CD4+ T cells contain a T-bethigh memory-phenotype (MP) population with innate-like functions. Here the authors characterize the requirements for their differentiation at homeostasis and identify a function for IL-12 that is tonically produced by type 1 dendritic cells in an MyD88- and CD40-dependent, but foreign PAMP-independent manner.Takeshi KawabeJaeu YiAkihisa KawajiriKerry HilliganDifeng FangNaoto IshiiHidehiro YamaneJinfang ZhuDragana JankovicKwang Soon KimGiorgio TrinchieriAlan SherNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takeshi Kawabe Jaeu Yi Akihisa Kawajiri Kerry Hilligan Difeng Fang Naoto Ishii Hidehiro Yamane Jinfang Zhu Dragana Jankovic Kwang Soon Kim Giorgio Trinchieri Alan Sher Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
description	CD4+ T cells contain a T-bethigh memory-phenotype (MP) population with innate-like functions. Here the authors characterize the requirements for their differentiation at homeostasis and identify a function for IL-12 that is tonically produced by type 1 dendritic cells in an MyD88- and CD40-dependent, but foreign PAMP-independent manner.
format	article
author	Takeshi Kawabe Jaeu Yi Akihisa Kawajiri Kerry Hilligan Difeng Fang Naoto Ishii Hidehiro Yamane Jinfang Zhu Dragana Jankovic Kwang Soon Kim Giorgio Trinchieri Alan Sher
author_facet	Takeshi Kawabe Jaeu Yi Akihisa Kawajiri Kerry Hilligan Difeng Fang Naoto Ishii Hidehiro Yamane Jinfang Zhu Dragana Jankovic Kwang Soon Kim Giorgio Trinchieri Alan Sher
author_sort	Takeshi Kawabe
title	Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
title_short	Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
title_full	Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
title_fullStr	Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
title_full_unstemmed	Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
title_sort	requirements for the differentiation of innate t-bethigh memory-phenotype cd4+ t lymphocytes under steady state
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ef3cb49a011444f1ac9d73d4ce336452
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Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state

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