Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.

Skeletal muscle atrophy can occur as a consequence of immobilization and/or starvation in the majority of vertebrates studied. In contrast, hibernating mammals are protected against the loss of muscle mass despite long periods of inactivity and lack of food intake. Resident muscle-specific stem cell...

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Autores principales:	Eva Andres-Mateos, Rebeca Mejias, Arshia Soleimani, Brian M Lin, Tyesha N Burks, Ruth Marx, Benjamin Lin, Richard C Zellars, Yonggang Zhang, David L Huso, Tom G Marr, Leslie A Leinwand, Dana K Merriman, Ronald D Cohn
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef4465b7d4724246ad44a972e47f3a2b
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spelling	oai:doaj.org-article:ef4465b7d4724246ad44a972e47f3a2b2021-11-18T08:08:52ZImpaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.1932-620310.1371/journal.pone.0048884https://doaj.org/article/ef4465b7d4724246ad44a972e47f3a2b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23155423/?tool=EBIhttps://doaj.org/toc/1932-6203Skeletal muscle atrophy can occur as a consequence of immobilization and/or starvation in the majority of vertebrates studied. In contrast, hibernating mammals are protected against the loss of muscle mass despite long periods of inactivity and lack of food intake. Resident muscle-specific stem cells (satellite cells) are known to be activated by muscle injury and their activation contributes to the regeneration of muscle, but whether satellite cells play a role in hibernation is unknown. In the hibernating 13-lined ground squirrel we show that muscles ablated of satellite cells were still protected against atrophy, demonstrating that satellite cells are not involved in the maintenance of skeletal muscle during hibernation. Additionally, hibernating skeletal muscle showed extremely slow regeneration in response to injury, due to repression of satellite cell activation and myoblast differentiation caused by a fine-tuned interplay of p21, myostatin, MAPK, and Wnt signaling pathways. Interestingly, despite long periods of inflammation and lack of efficient regeneration, injured skeletal muscle from hibernating animals did not develop fibrosis and was capable of complete recovery when animals emerged naturally from hibernation. We propose that hibernating squirrels represent a new model system that permits evaluation of impaired skeletal muscle remodeling in the absence of formation of tissue fibrosis.Eva Andres-MateosRebeca MejiasArshia SoleimaniBrian M LinTyesha N BurksRuth MarxBenjamin LinRichard C ZellarsYonggang ZhangDavid L HusoTom G MarrLeslie A LeinwandDana K MerrimanRonald D CohnPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48884 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eva Andres-Mateos Rebeca Mejias Arshia Soleimani Brian M Lin Tyesha N Burks Ruth Marx Benjamin Lin Richard C Zellars Yonggang Zhang David L Huso Tom G Marr Leslie A Leinwand Dana K Merriman Ronald D Cohn Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.
description	Skeletal muscle atrophy can occur as a consequence of immobilization and/or starvation in the majority of vertebrates studied. In contrast, hibernating mammals are protected against the loss of muscle mass despite long periods of inactivity and lack of food intake. Resident muscle-specific stem cells (satellite cells) are known to be activated by muscle injury and their activation contributes to the regeneration of muscle, but whether satellite cells play a role in hibernation is unknown. In the hibernating 13-lined ground squirrel we show that muscles ablated of satellite cells were still protected against atrophy, demonstrating that satellite cells are not involved in the maintenance of skeletal muscle during hibernation. Additionally, hibernating skeletal muscle showed extremely slow regeneration in response to injury, due to repression of satellite cell activation and myoblast differentiation caused by a fine-tuned interplay of p21, myostatin, MAPK, and Wnt signaling pathways. Interestingly, despite long periods of inflammation and lack of efficient regeneration, injured skeletal muscle from hibernating animals did not develop fibrosis and was capable of complete recovery when animals emerged naturally from hibernation. We propose that hibernating squirrels represent a new model system that permits evaluation of impaired skeletal muscle remodeling in the absence of formation of tissue fibrosis.
format	article
author	Eva Andres-Mateos Rebeca Mejias Arshia Soleimani Brian M Lin Tyesha N Burks Ruth Marx Benjamin Lin Richard C Zellars Yonggang Zhang David L Huso Tom G Marr Leslie A Leinwand Dana K Merriman Ronald D Cohn
author_facet	Eva Andres-Mateos Rebeca Mejias Arshia Soleimani Brian M Lin Tyesha N Burks Ruth Marx Benjamin Lin Richard C Zellars Yonggang Zhang David L Huso Tom G Marr Leslie A Leinwand Dana K Merriman Ronald D Cohn
author_sort	Eva Andres-Mateos
title	Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.
title_short	Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.
title_full	Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.
title_fullStr	Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.
title_full_unstemmed	Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.
title_sort	impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ef4465b7d4724246ad44a972e47f3a2b
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Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.

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