Selective inhibition of small-diameter axons using infrared light

Abstract Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the first time, we demonstrate that IR can selectively...

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Autores principales:	Emilie H. Lothet, Kendrick M. Shaw, Hui Lu, Junqi Zhuo, Yves T. Wang, Shi Gu, Donna B. Stolz, E. Duco Jansen, Charles C. Horn, Hillel J. Chiel, Michael W. Jenkins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef485175ef8c4bb4ada77f91c156fa83
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spelling	oai:doaj.org-article:ef485175ef8c4bb4ada77f91c156fa832021-12-02T12:32:06ZSelective inhibition of small-diameter axons using infrared light10.1038/s41598-017-03374-92045-2322https://doaj.org/article/ef485175ef8c4bb4ada77f91c156fa832017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03374-9https://doaj.org/toc/2045-2322Abstract Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the first time, we demonstrate that IR can selectively and reversibly inhibit small-diameter axons at lower radiant exposures than large-diameter axons. We provide a mathematical rationale, and then demonstrate it experimentally in individual axons of identified neurons in the marine mollusk Aplysia californica, and in axons within the vagus nerve of a mammal, the musk shrew Suncus murinus. The ability to selectively, rapidly, and reversibly control small-diameter sensory fibers may have many applications, both for the analysis of physiology, and for treating diseases of the peripheral nervous system, such as chronic nausea, vomiting, pain, and hypertension. Moreover, the mathematical analysis of how IR affects the nerve could apply to other techniques for controlling peripheral nerve signaling.Emilie H. LothetKendrick M. ShawHui LuJunqi ZhuoYves T. WangShi GuDonna B. StolzE. Duco JansenCharles C. HornHillel J. ChielMichael W. JenkinsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emilie H. Lothet Kendrick M. Shaw Hui Lu Junqi Zhuo Yves T. Wang Shi Gu Donna B. Stolz E. Duco Jansen Charles C. Horn Hillel J. Chiel Michael W. Jenkins Selective inhibition of small-diameter axons using infrared light
description	Abstract Novel clinical treatments to target peripheral nerves are being developed which primarily use electrical current. Recently, infrared (IR) light was shown to inhibit peripheral nerves with high spatial and temporal specificity. Here, for the first time, we demonstrate that IR can selectively and reversibly inhibit small-diameter axons at lower radiant exposures than large-diameter axons. We provide a mathematical rationale, and then demonstrate it experimentally in individual axons of identified neurons in the marine mollusk Aplysia californica, and in axons within the vagus nerve of a mammal, the musk shrew Suncus murinus. The ability to selectively, rapidly, and reversibly control small-diameter sensory fibers may have many applications, both for the analysis of physiology, and for treating diseases of the peripheral nervous system, such as chronic nausea, vomiting, pain, and hypertension. Moreover, the mathematical analysis of how IR affects the nerve could apply to other techniques for controlling peripheral nerve signaling.
format	article
author	Emilie H. Lothet Kendrick M. Shaw Hui Lu Junqi Zhuo Yves T. Wang Shi Gu Donna B. Stolz E. Duco Jansen Charles C. Horn Hillel J. Chiel Michael W. Jenkins
author_facet	Emilie H. Lothet Kendrick M. Shaw Hui Lu Junqi Zhuo Yves T. Wang Shi Gu Donna B. Stolz E. Duco Jansen Charles C. Horn Hillel J. Chiel Michael W. Jenkins
author_sort	Emilie H. Lothet
title	Selective inhibition of small-diameter axons using infrared light
title_short	Selective inhibition of small-diameter axons using infrared light
title_full	Selective inhibition of small-diameter axons using infrared light
title_fullStr	Selective inhibition of small-diameter axons using infrared light
title_full_unstemmed	Selective inhibition of small-diameter axons using infrared light
title_sort	selective inhibition of small-diameter axons using infrared light
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ef485175ef8c4bb4ada77f91c156fa83
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Selective inhibition of small-diameter axons using infrared light

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