tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence

Mycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovisBCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use of synonymous codons in survival genes.

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Autores principales:	Yok Hian Chionh, Megan McBee, I. Ramesh Babu, Fabian Hia, Wenwei Lin, Wei Zhao, Jianshu Cao, Agnieszka Dziergowska, Andrzej Malkiewicz, Thomas J. Begley, Sylvie Alonso, Peter C. Dedon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef49a7068372488eae9591272d451d23
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spelling	oai:doaj.org-article:ef49a7068372488eae9591272d451d232021-12-02T16:57:03ZtRNA-mediated codon-biased translation in mycobacterial hypoxic persistence10.1038/ncomms133022041-1723https://doaj.org/article/ef49a7068372488eae9591272d451d232016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13302https://doaj.org/toc/2041-1723Mycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovisBCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use of synonymous codons in survival genes.Yok Hian ChionhMegan McBeeI. Ramesh BabuFabian HiaWenwei LinWei ZhaoJianshu CaoAgnieszka DziergowskaAndrzej MalkiewiczThomas J. BegleySylvie AlonsoPeter C. DedonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yok Hian Chionh Megan McBee I. Ramesh Babu Fabian Hia Wenwei Lin Wei Zhao Jianshu Cao Agnieszka Dziergowska Andrzej Malkiewicz Thomas J. Begley Sylvie Alonso Peter C. Dedon tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
description	Mycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovisBCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use of synonymous codons in survival genes.
format	article
author	Yok Hian Chionh Megan McBee I. Ramesh Babu Fabian Hia Wenwei Lin Wei Zhao Jianshu Cao Agnieszka Dziergowska Andrzej Malkiewicz Thomas J. Begley Sylvie Alonso Peter C. Dedon
author_facet	Yok Hian Chionh Megan McBee I. Ramesh Babu Fabian Hia Wenwei Lin Wei Zhao Jianshu Cao Agnieszka Dziergowska Andrzej Malkiewicz Thomas J. Begley Sylvie Alonso Peter C. Dedon
author_sort	Yok Hian Chionh
title	tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
title_short	tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
title_full	tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
title_fullStr	tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
title_full_unstemmed	tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
title_sort	trna-mediated codon-biased translation in mycobacterial hypoxic persistence
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ef49a7068372488eae9591272d451d23
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tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence

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