The clinical associations with cardiomegaly in patients undergoing evaluation for pulmonary hypertension
Background Chest radiographs can identify important abnormalities in patients undergoing diagnostic evaluation for cardiovascular diseases. Cardiomegaly often reflects cardiac chamber dilation, or cardiac muscle hypertrophy, or both conditions. The clinical implications of cardiomegaly depend on the...
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Taylor & Francis Group
2021
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oai:doaj.org-article:ef49f07253294e7aae378a6e8cd5181d2021-11-17T14:21:57ZThe clinical associations with cardiomegaly in patients undergoing evaluation for pulmonary hypertension2000-966610.1080/20009666.2021.1982488https://doaj.org/article/ef49f07253294e7aae378a6e8cd5181d2021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/20009666.2021.1982488https://doaj.org/toc/2000-9666Background Chest radiographs can identify important abnormalities in patients undergoing diagnostic evaluation for cardiovascular diseases. Cardiomegaly often reflects cardiac chamber dilation, or cardiac muscle hypertrophy, or both conditions. The clinical implications of cardiomegaly depend on the underlying clinical disorder. Does cardiomegaly have any clinical, laboratory, echocardiographic, and right heart catheterization associations in patients undergoing evaluation for pulmonary hypertension? Methods Patients referred to a pulmonary vascular disease clinic for possible pulmonary hypertension underwent a comprehensive evaluation that included right heart catheterization. These patients also had chest radiographs, laboratory studies, and echocardiograms. The patients were divided into two groups based on the presence or absence of cardiomegaly. Results This study included 102 patients (63.7% female) with a mean age of 62.3 ± 15.0 years. Patients with cardiomegaly (n = 64) had elevated BNP, BUN, and creatinine levels. They had elevated right atrial pressures, right ventricular pressures, and pulmonary artery pressures and reduced cardiac indices and reduced mixed venous oxygen saturations. There were no differences in echocardiographic parameters between the two groups. Conclusions This study demonstrates that the presence of cardiomegaly on chest radiographs has important clinical implications, including increased BNP levels and increased right heart pressures, in patients undergoing evaluation for pulmonary hypertension. Consequently, the presence of cardiomegaly supports the need for additional evaluation, including right heart catheterization, and provides useful information for primary care physicians and specialists.Benjamin DainesSanjana RaoOmid HosseiniSofia PrietoJohn AbdelmalekMohamed ElmassryPooja SethiVictor TestKenneth NugentTaylor & Francis Grouparticlecardiomegalypulmonary hypertensionright heart catheterizationechocardiographyInternal medicineRC31-1245ENJournal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 787-792 (2021) |
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cardiomegaly pulmonary hypertension right heart catheterization echocardiography Internal medicine RC31-1245 |
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cardiomegaly pulmonary hypertension right heart catheterization echocardiography Internal medicine RC31-1245 Benjamin Daines Sanjana Rao Omid Hosseini Sofia Prieto John Abdelmalek Mohamed Elmassry Pooja Sethi Victor Test Kenneth Nugent The clinical associations with cardiomegaly in patients undergoing evaluation for pulmonary hypertension |
| description |
Background Chest radiographs can identify important abnormalities in patients undergoing diagnostic evaluation for cardiovascular diseases. Cardiomegaly often reflects cardiac chamber dilation, or cardiac muscle hypertrophy, or both conditions. The clinical implications of cardiomegaly depend on the underlying clinical disorder. Does cardiomegaly have any clinical, laboratory, echocardiographic, and right heart catheterization associations in patients undergoing evaluation for pulmonary hypertension? Methods Patients referred to a pulmonary vascular disease clinic for possible pulmonary hypertension underwent a comprehensive evaluation that included right heart catheterization. These patients also had chest radiographs, laboratory studies, and echocardiograms. The patients were divided into two groups based on the presence or absence of cardiomegaly. Results This study included 102 patients (63.7% female) with a mean age of 62.3 ± 15.0 years. Patients with cardiomegaly (n = 64) had elevated BNP, BUN, and creatinine levels. They had elevated right atrial pressures, right ventricular pressures, and pulmonary artery pressures and reduced cardiac indices and reduced mixed venous oxygen saturations. There were no differences in echocardiographic parameters between the two groups. Conclusions This study demonstrates that the presence of cardiomegaly on chest radiographs has important clinical implications, including increased BNP levels and increased right heart pressures, in patients undergoing evaluation for pulmonary hypertension. Consequently, the presence of cardiomegaly supports the need for additional evaluation, including right heart catheterization, and provides useful information for primary care physicians and specialists. |
| format |
article |
| author |
Benjamin Daines Sanjana Rao Omid Hosseini Sofia Prieto John Abdelmalek Mohamed Elmassry Pooja Sethi Victor Test Kenneth Nugent |
| author_facet |
Benjamin Daines Sanjana Rao Omid Hosseini Sofia Prieto John Abdelmalek Mohamed Elmassry Pooja Sethi Victor Test Kenneth Nugent |
| author_sort |
Benjamin Daines |
| title |
The clinical associations with cardiomegaly in patients undergoing evaluation for pulmonary hypertension |
| title_short |
The clinical associations with cardiomegaly in patients undergoing evaluation for pulmonary hypertension |
| title_full |
The clinical associations with cardiomegaly in patients undergoing evaluation for pulmonary hypertension |
| title_fullStr |
The clinical associations with cardiomegaly in patients undergoing evaluation for pulmonary hypertension |
| title_full_unstemmed |
The clinical associations with cardiomegaly in patients undergoing evaluation for pulmonary hypertension |
| title_sort |
clinical associations with cardiomegaly in patients undergoing evaluation for pulmonary hypertension |
| publisher |
Taylor & Francis Group |
| publishDate |
2021 |
| url |
https://doaj.org/article/ef49f07253294e7aae378a6e8cd5181d |
| work_keys_str_mv |
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