Dietary Iron Overload and <i>Hfe<sup>−/−</sup></i> Related Hemochromatosis Alter Hepatic Mitochondrial Function

Dietary Iron Overload and <i>Hfe<sup>−/−</sup></i> Related Hemochromatosis Alter Hepatic Mitochondrial Function

Iron is an essential co-factor for many cellular metabolic processes, and mitochondria are main sites of utilization. Iron accumulation promotes production of reactive oxygen species (ROS) via the catalytic activity of iron species. Herein, we investigated the consequences of dietary and genetic iro...

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Autores principales: Christine Fischer, Chiara Volani, Timea Komlódi, Markus Seifert, Egon Demetz, Lara Valente de Souza, Kristina Auer, Verena Petzer, Laura von Raffay, Patrizia Moser, Erich Gnaiger, Guenter Weiss
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
hemochromatosis
iron overload
reactive oxygen species
mitochondria
mitochondrial respiration
liver
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/ef4b4e66d0a84ee18a98a6038736a687
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