Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018

Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans and dromedary camels and is responsible for an ongoing outbreak of severe respiratory illness in humans in the Middle East. Although some mutations found in camel-derived MERS-CoV strains have been characterized, most natural va...

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Autores principales:	Neeltje van Doremalen, Michael Letko, Robert J. Fischer, Trenton Bushmaker, Jonathan Schulz, Claude K. Yinda, Stephanie N. Seifert, Nam Joong Kim, Maged G. Hemida, Ghazi Kayali, Wan Beom Park, Ranawaka A.P.M. Perera, Azaibi Tamin, Natalie J. Thornburg, Suxiang Tong, Krista Queen, Maria D. van Kerkhove, Young Ki Choi, Myoung-don Oh, Abdullah M. Assiri, Malik Peiris, Susan I. Gerber, Vincent J. Munster
Formato:	article
Lenguaje:	EN
Publicado:	Centers for Disease Control and Prevention 2021
Materias:	Middle East respiratory syndrome coronavirus MERS-CoV coronavirus viruses severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Medicine R Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/ef527a90ad7d42f4973f658f51a49272
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spelling	oai:doaj.org-article:ef527a90ad7d42f4973f658f51a492722021-11-22T12:57:08ZSurface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒201810.3201/eid2712.2103441080-60401080-6059https://doaj.org/article/ef527a90ad7d42f4973f658f51a492722021-12-01T00:00:00Zhttps://wwwnc.cdc.gov/eid/article/27/12/21-0344_articlehttps://doaj.org/toc/1080-6040https://doaj.org/toc/1080-6059 Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans and dromedary camels and is responsible for an ongoing outbreak of severe respiratory illness in humans in the Middle East. Although some mutations found in camel-derived MERS-CoV strains have been characterized, most natural variation found across MERS-CoV isolates remains unstudied. We report on the environmental stability, replication kinetics, and pathogenicity of several diverse isolates of MERS-CoV, as well as isolates of severe acute respiratory syndrome coronavirus 2, to serve as a basis of comparison with other stability studies. Although most MERS-CoV isolates had similar stability and pathogenicity in our experiments, the camel-derived isolate C/KSA/13 had reduced surface stability, and another camel isolate, C/BF/15, had reduced pathogenicity in a small animal model. These results suggest that although betacoronaviruses might have similar environmental stability profiles, individual variation can influence this phenotype, underscoring the need for continual global viral surveillance. Neeltje van DoremalenMichael LetkoRobert J. FischerTrenton BushmakerJonathan SchulzClaude K. YindaStephanie N. SeifertNam Joong KimMaged G. HemidaGhazi KayaliWan Beom ParkRanawaka A.P.M. PereraAzaibi TaminNatalie J. ThornburgSuxiang TongKrista QueenMaria D. van KerkhoveYoung Ki ChoiMyoung-don OhAbdullah M. AssiriMalik PeirisSusan I. GerberVincent J. MunsterCenters for Disease Control and PreventionarticleMiddle East respiratory syndrome coronavirusMERS-CoVcoronavirusvirusessevere acute respiratory syndrome coronavirus 2SARS-CoV-2MedicineRInfectious and parasitic diseasesRC109-216ENEmerging Infectious Diseases, Vol 27, Iss 12, Pp 3052-3062 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Middle East respiratory syndrome coronavirus MERS-CoV coronavirus viruses severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Medicine R Infectious and parasitic diseases RC109-216
spellingShingle	Middle East respiratory syndrome coronavirus MERS-CoV coronavirus viruses severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Medicine R Infectious and parasitic diseases RC109-216 Neeltje van Doremalen Michael Letko Robert J. Fischer Trenton Bushmaker Jonathan Schulz Claude K. Yinda Stephanie N. Seifert Nam Joong Kim Maged G. Hemida Ghazi Kayali Wan Beom Park Ranawaka A.P.M. Perera Azaibi Tamin Natalie J. Thornburg Suxiang Tong Krista Queen Maria D. van Kerkhove Young Ki Choi Myoung-don Oh Abdullah M. Assiri Malik Peiris Susan I. Gerber Vincent J. Munster Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018
description	Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans and dromedary camels and is responsible for an ongoing outbreak of severe respiratory illness in humans in the Middle East. Although some mutations found in camel-derived MERS-CoV strains have been characterized, most natural variation found across MERS-CoV isolates remains unstudied. We report on the environmental stability, replication kinetics, and pathogenicity of several diverse isolates of MERS-CoV, as well as isolates of severe acute respiratory syndrome coronavirus 2, to serve as a basis of comparison with other stability studies. Although most MERS-CoV isolates had similar stability and pathogenicity in our experiments, the camel-derived isolate C/KSA/13 had reduced surface stability, and another camel isolate, C/BF/15, had reduced pathogenicity in a small animal model. These results suggest that although betacoronaviruses might have similar environmental stability profiles, individual variation can influence this phenotype, underscoring the need for continual global viral surveillance.
format	article
author	Neeltje van Doremalen Michael Letko Robert J. Fischer Trenton Bushmaker Jonathan Schulz Claude K. Yinda Stephanie N. Seifert Nam Joong Kim Maged G. Hemida Ghazi Kayali Wan Beom Park Ranawaka A.P.M. Perera Azaibi Tamin Natalie J. Thornburg Suxiang Tong Krista Queen Maria D. van Kerkhove Young Ki Choi Myoung-don Oh Abdullah M. Assiri Malik Peiris Susan I. Gerber Vincent J. Munster
author_facet	Neeltje van Doremalen Michael Letko Robert J. Fischer Trenton Bushmaker Jonathan Schulz Claude K. Yinda Stephanie N. Seifert Nam Joong Kim Maged G. Hemida Ghazi Kayali Wan Beom Park Ranawaka A.P.M. Perera Azaibi Tamin Natalie J. Thornburg Suxiang Tong Krista Queen Maria D. van Kerkhove Young Ki Choi Myoung-don Oh Abdullah M. Assiri Malik Peiris Susan I. Gerber Vincent J. Munster
author_sort	Neeltje van Doremalen
title	Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018
title_short	Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018
title_full	Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018
title_fullStr	Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018
title_full_unstemmed	Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018
title_sort	surface‒aerosol stability and pathogenicity of diverse middle east respiratory syndrome coronavirus strains, 2012‒2018
publisher	Centers for Disease Control and Prevention
publishDate	2021
url	https://doaj.org/article/ef527a90ad7d42f4973f658f51a49272
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Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018

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