HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

Mitophagy is crucial for mitochondrial quality control and maintenance of cellular homeostasis. Here the authors identify an E3 ubiquitin ligase, HUWE1, that collaborates with LC3-interacting protein AMBRA1 to induce mitochondrial clearance.

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Autores principales: Anthea Di Rita, Angelo Peschiaroli, Pasquale D′Acunzo, Daniela Strobbe, Zehan Hu, Jens Gruber, Mads Nygaard, Matteo Lambrughi, Gerry Melino, Elena Papaleo, Jörn Dengjel, Said El Alaoui, Michelangelo Campanella, Volker Dötsch, Vladimir V. Rogov, Flavie Strappazzon, Francesco Cecconi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/ef54c1bc371f46c7a0abb9f445a40480
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spelling oai:doaj.org-article:ef54c1bc371f46c7a0abb9f445a404802021-12-02T14:40:08ZHUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα10.1038/s41467-018-05722-32041-1723https://doaj.org/article/ef54c1bc371f46c7a0abb9f445a404802018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05722-3https://doaj.org/toc/2041-1723Mitophagy is crucial for mitochondrial quality control and maintenance of cellular homeostasis. Here the authors identify an E3 ubiquitin ligase, HUWE1, that collaborates with LC3-interacting protein AMBRA1 to induce mitochondrial clearance.Anthea Di RitaAngelo PeschiaroliPasquale D′AcunzoDaniela StrobbeZehan HuJens GruberMads NygaardMatteo LambrughiGerry MelinoElena PapaleoJörn DengjelSaid El AlaouiMichelangelo CampanellaVolker DötschVladimir V. RogovFlavie StrappazzonFrancesco CecconiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anthea Di Rita
Angelo Peschiaroli
Pasquale D′Acunzo
Daniela Strobbe
Zehan Hu
Jens Gruber
Mads Nygaard
Matteo Lambrughi
Gerry Melino
Elena Papaleo
Jörn Dengjel
Said El Alaoui
Michelangelo Campanella
Volker Dötsch
Vladimir V. Rogov
Flavie Strappazzon
Francesco Cecconi
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
description Mitophagy is crucial for mitochondrial quality control and maintenance of cellular homeostasis. Here the authors identify an E3 ubiquitin ligase, HUWE1, that collaborates with LC3-interacting protein AMBRA1 to induce mitochondrial clearance.
format article
author Anthea Di Rita
Angelo Peschiaroli
Pasquale D′Acunzo
Daniela Strobbe
Zehan Hu
Jens Gruber
Mads Nygaard
Matteo Lambrughi
Gerry Melino
Elena Papaleo
Jörn Dengjel
Said El Alaoui
Michelangelo Campanella
Volker Dötsch
Vladimir V. Rogov
Flavie Strappazzon
Francesco Cecconi
author_facet Anthea Di Rita
Angelo Peschiaroli
Pasquale D′Acunzo
Daniela Strobbe
Zehan Hu
Jens Gruber
Mads Nygaard
Matteo Lambrughi
Gerry Melino
Elena Papaleo
Jörn Dengjel
Said El Alaoui
Michelangelo Campanella
Volker Dötsch
Vladimir V. Rogov
Flavie Strappazzon
Francesco Cecconi
author_sort Anthea Di Rita
title HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
title_short HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
title_full HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
title_fullStr HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
title_full_unstemmed HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
title_sort huwe1 e3 ligase promotes pink1/parkin-independent mitophagy by regulating ambra1 activation via ikkα
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ef54c1bc371f46c7a0abb9f445a40480
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