Framework nucleic acids as programmable carrier for transdermal drug delivery

DNA nanostructures hold great promise for drug delivery, but systemic administration is problematic. Here, the authors demonstrate that framework nucleic acids (FNAs) improve drug accumulation in tumours in topical application and that penetration depth is controllable through adjusting FNA size.

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Detalles Bibliográficos
Autores principales:	Christian Wiraja, Ying Zhu, Daniel Chin Shiuan Lio, David C. Yeo, Mo Xie, Weina Fang, Qian Li, Mengjia Zheng, Maurice Van Steensel, Lihua Wang, Chunhai Fan, Chenjie Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef54f0f852fc4fcb904c891861e35567
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spelling	oai:doaj.org-article:ef54f0f852fc4fcb904c891861e355672021-12-02T16:50:59ZFramework nucleic acids as programmable carrier for transdermal drug delivery10.1038/s41467-019-09029-92041-1723https://doaj.org/article/ef54f0f852fc4fcb904c891861e355672019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09029-9https://doaj.org/toc/2041-1723DNA nanostructures hold great promise for drug delivery, but systemic administration is problematic. Here, the authors demonstrate that framework nucleic acids (FNAs) improve drug accumulation in tumours in topical application and that penetration depth is controllable through adjusting FNA size.Christian WirajaYing ZhuDaniel Chin Shiuan LioDavid C. YeoMo XieWeina FangQian LiMengjia ZhengMaurice Van SteenselLihua WangChunhai FanChenjie XuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian Wiraja Ying Zhu Daniel Chin Shiuan Lio David C. Yeo Mo Xie Weina Fang Qian Li Mengjia Zheng Maurice Van Steensel Lihua Wang Chunhai Fan Chenjie Xu Framework nucleic acids as programmable carrier for transdermal drug delivery
description	DNA nanostructures hold great promise for drug delivery, but systemic administration is problematic. Here, the authors demonstrate that framework nucleic acids (FNAs) improve drug accumulation in tumours in topical application and that penetration depth is controllable through adjusting FNA size.
format	article
author	Christian Wiraja Ying Zhu Daniel Chin Shiuan Lio David C. Yeo Mo Xie Weina Fang Qian Li Mengjia Zheng Maurice Van Steensel Lihua Wang Chunhai Fan Chenjie Xu
author_facet	Christian Wiraja Ying Zhu Daniel Chin Shiuan Lio David C. Yeo Mo Xie Weina Fang Qian Li Mengjia Zheng Maurice Van Steensel Lihua Wang Chunhai Fan Chenjie Xu
author_sort	Christian Wiraja
title	Framework nucleic acids as programmable carrier for transdermal drug delivery
title_short	Framework nucleic acids as programmable carrier for transdermal drug delivery
title_full	Framework nucleic acids as programmable carrier for transdermal drug delivery
title_fullStr	Framework nucleic acids as programmable carrier for transdermal drug delivery
title_full_unstemmed	Framework nucleic acids as programmable carrier for transdermal drug delivery
title_sort	framework nucleic acids as programmable carrier for transdermal drug delivery
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ef54f0f852fc4fcb904c891861e35567
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Framework nucleic acids as programmable carrier for transdermal drug delivery

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