Circadian regulation of vertebrate cone photoreceptor function

Eukaryotes generally display a circadian rhythm as an adaption to the reoccurring day/night cycle. This is particularly true for visual physiology that is directly affected by changing light conditions. Here we investigate the influence of the circadian rhythm on the expression and function of visua...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jingjing Zang, Matthias Gesemann, Jennifer Keim, Marijana Samardzija, Christian Grimm, Stephan CF Neuhauss
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	circadian rhythm visual transduction cascade retina electroretinography visual behavior Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ef592232620c4eda93d202457d500cc3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ef592232620c4eda93d202457d500cc3
record_format	dspace
spelling	oai:doaj.org-article:ef592232620c4eda93d202457d500cc32021-11-26T07:05:29ZCircadian regulation of vertebrate cone photoreceptor function10.7554/eLife.689032050-084Xe68903https://doaj.org/article/ef592232620c4eda93d202457d500cc32021-09-01T00:00:00Zhttps://elifesciences.org/articles/68903https://doaj.org/toc/2050-084XEukaryotes generally display a circadian rhythm as an adaption to the reoccurring day/night cycle. This is particularly true for visual physiology that is directly affected by changing light conditions. Here we investigate the influence of the circadian rhythm on the expression and function of visual transduction cascade regulators in diurnal zebrafish and nocturnal mice. We focused on regulators of shut-off kinetics such as Recoverins, Arrestins, Opsin kinases, and Regulator of G-protein signaling that have direct effects on temporal vision. Transcript as well as protein levels of most analyzed genes show a robust circadian rhythm-dependent regulation, which correlates with changes in photoresponse kinetics. Electroretinography demonstrates that photoresponse recovery in zebrafish is delayed in the evening and accelerated in the morning. Functional rhythmicity persists in continuous darkness, and it is reversed by an inverted light cycle and disrupted by constant light. This is in line with our finding that orthologous gene transcripts from diurnal zebrafish and nocturnal mice are often expressed in an anti-phasic daily rhythm.Jingjing ZangMatthias GesemannJennifer KeimMarijana SamardzijaChristian GrimmStephan CF NeuhausseLife Sciences Publications Ltdarticlecircadian rhythmvisual transduction cascaderetinaelectroretinographyvisual behaviorMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circadian rhythm visual transduction cascade retina electroretinography visual behavior Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	circadian rhythm visual transduction cascade retina electroretinography visual behavior Medicine R Science Q Biology (General) QH301-705.5 Jingjing Zang Matthias Gesemann Jennifer Keim Marijana Samardzija Christian Grimm Stephan CF Neuhauss Circadian regulation of vertebrate cone photoreceptor function
description	Eukaryotes generally display a circadian rhythm as an adaption to the reoccurring day/night cycle. This is particularly true for visual physiology that is directly affected by changing light conditions. Here we investigate the influence of the circadian rhythm on the expression and function of visual transduction cascade regulators in diurnal zebrafish and nocturnal mice. We focused on regulators of shut-off kinetics such as Recoverins, Arrestins, Opsin kinases, and Regulator of G-protein signaling that have direct effects on temporal vision. Transcript as well as protein levels of most analyzed genes show a robust circadian rhythm-dependent regulation, which correlates with changes in photoresponse kinetics. Electroretinography demonstrates that photoresponse recovery in zebrafish is delayed in the evening and accelerated in the morning. Functional rhythmicity persists in continuous darkness, and it is reversed by an inverted light cycle and disrupted by constant light. This is in line with our finding that orthologous gene transcripts from diurnal zebrafish and nocturnal mice are often expressed in an anti-phasic daily rhythm.
format	article
author	Jingjing Zang Matthias Gesemann Jennifer Keim Marijana Samardzija Christian Grimm Stephan CF Neuhauss
author_facet	Jingjing Zang Matthias Gesemann Jennifer Keim Marijana Samardzija Christian Grimm Stephan CF Neuhauss
author_sort	Jingjing Zang
title	Circadian regulation of vertebrate cone photoreceptor function
title_short	Circadian regulation of vertebrate cone photoreceptor function
title_full	Circadian regulation of vertebrate cone photoreceptor function
title_fullStr	Circadian regulation of vertebrate cone photoreceptor function
title_full_unstemmed	Circadian regulation of vertebrate cone photoreceptor function
title_sort	circadian regulation of vertebrate cone photoreceptor function
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/ef592232620c4eda93d202457d500cc3
work_keys_str_mv	AT jingjingzang circadianregulationofvertebrateconephotoreceptorfunction AT matthiasgesemann circadianregulationofvertebrateconephotoreceptorfunction AT jenniferkeim circadianregulationofvertebrateconephotoreceptorfunction AT marijanasamardzija circadianregulationofvertebrateconephotoreceptorfunction AT christiangrimm circadianregulationofvertebrateconephotoreceptorfunction AT stephancfneuhauss circadianregulationofvertebrateconephotoreceptorfunction
_version_	1718409753936265216

Circadian regulation of vertebrate cone photoreceptor function

Ejemplares similares