Molecular insights into antibiotic resistance - how a binding protein traps albicidin

The potent antibacterial compound albicidin is synthesized by the plant-pathogenic bacterium Xanthomonas albilineans. Here the authors employ a multidisciplinary approach and provide structural and mechanistic insights into how the drug-binding protein AlbA confers albicidin resistance to Klebsiella...

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Autores principales:	Lida Rostock, Ronja Driller, Stefan Grätz, Dennis Kerwat, Leonard von Eckardstein, Daniel Petras, Maria Kunert, Claudia Alings, Franz-Josef Schmitt, Thomas Friedrich, Markus C. Wahl, Bernhard Loll, Andi Mainz, Roderich D. Süssmuth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef5cd126b6d942939a1a01e88363268b
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spelling	oai:doaj.org-article:ef5cd126b6d942939a1a01e88363268b2021-12-02T16:57:00ZMolecular insights into antibiotic resistance - how a binding protein traps albicidin10.1038/s41467-018-05551-42041-1723https://doaj.org/article/ef5cd126b6d942939a1a01e88363268b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05551-4https://doaj.org/toc/2041-1723The potent antibacterial compound albicidin is synthesized by the plant-pathogenic bacterium Xanthomonas albilineans. Here the authors employ a multidisciplinary approach and provide structural and mechanistic insights into how the drug-binding protein AlbA confers albicidin resistance to Klebsiella oxytoca.Lida RostockRonja DrillerStefan GrätzDennis KerwatLeonard von EckardsteinDaniel PetrasMaria KunertClaudia AlingsFranz-Josef SchmittThomas FriedrichMarkus C. WahlBernhard LollAndi MainzRoderich D. SüssmuthNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lida Rostock Ronja Driller Stefan Grätz Dennis Kerwat Leonard von Eckardstein Daniel Petras Maria Kunert Claudia Alings Franz-Josef Schmitt Thomas Friedrich Markus C. Wahl Bernhard Loll Andi Mainz Roderich D. Süssmuth Molecular insights into antibiotic resistance - how a binding protein traps albicidin
description	The potent antibacterial compound albicidin is synthesized by the plant-pathogenic bacterium Xanthomonas albilineans. Here the authors employ a multidisciplinary approach and provide structural and mechanistic insights into how the drug-binding protein AlbA confers albicidin resistance to Klebsiella oxytoca.
format	article
author	Lida Rostock Ronja Driller Stefan Grätz Dennis Kerwat Leonard von Eckardstein Daniel Petras Maria Kunert Claudia Alings Franz-Josef Schmitt Thomas Friedrich Markus C. Wahl Bernhard Loll Andi Mainz Roderich D. Süssmuth
author_facet	Lida Rostock Ronja Driller Stefan Grätz Dennis Kerwat Leonard von Eckardstein Daniel Petras Maria Kunert Claudia Alings Franz-Josef Schmitt Thomas Friedrich Markus C. Wahl Bernhard Loll Andi Mainz Roderich D. Süssmuth
author_sort	Lida Rostock
title	Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_short	Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_full	Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_fullStr	Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_full_unstemmed	Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_sort	molecular insights into antibiotic resistance - how a binding protein traps albicidin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ef5cd126b6d942939a1a01e88363268b
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Molecular insights into antibiotic resistance - how a binding protein traps albicidin

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