Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

Autophagy is a cellular process for recycling cell constituents, and is essential for T cell activation, but its function in T cell polarization is still unclear. Here the authors show that autophagy induces the degradation of transcription factor PU.1 to negatively modulate TH9 homeostasis and anti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Thaiz Rivera Vargas, Zhijian Cai, Yingying Shen, Magalie Dosset, Isis Benoit-Lizon, Tiffany Martin, Aurélie Roussey, Richard A. Flavell, François Ghiringhelli, Lionel Apetoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef5f37a4be9a43188f9b499831b2af44
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ef5f37a4be9a43188f9b499831b2af44
record_format	dspace
spelling	oai:doaj.org-article:ef5f37a4be9a43188f9b499831b2af442021-12-02T15:37:01ZSelective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells10.1038/s41467-017-00468-w2041-1723https://doaj.org/article/ef5f37a4be9a43188f9b499831b2af442017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00468-whttps://doaj.org/toc/2041-1723Autophagy is a cellular process for recycling cell constituents, and is essential for T cell activation, but its function in T cell polarization is still unclear. Here the authors show that autophagy induces the degradation of transcription factor PU.1 to negatively modulate TH9 homeostasis and antitumour immunity.Thaiz Rivera VargasZhijian CaiYingying ShenMagalie DossetIsis Benoit-LizonTiffany MartinAurélie RousseyRichard A. FlavellFrançois GhiringhelliLionel ApetohNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thaiz Rivera Vargas Zhijian Cai Yingying Shen Magalie Dosset Isis Benoit-Lizon Tiffany Martin Aurélie Roussey Richard A. Flavell François Ghiringhelli Lionel Apetoh Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
description	Autophagy is a cellular process for recycling cell constituents, and is essential for T cell activation, but its function in T cell polarization is still unclear. Here the authors show that autophagy induces the degradation of transcription factor PU.1 to negatively modulate TH9 homeostasis and antitumour immunity.
format	article
author	Thaiz Rivera Vargas Zhijian Cai Yingying Shen Magalie Dosset Isis Benoit-Lizon Tiffany Martin Aurélie Roussey Richard A. Flavell François Ghiringhelli Lionel Apetoh
author_facet	Thaiz Rivera Vargas Zhijian Cai Yingying Shen Magalie Dosset Isis Benoit-Lizon Tiffany Martin Aurélie Roussey Richard A. Flavell François Ghiringhelli Lionel Apetoh
author_sort	Thaiz Rivera Vargas
title	Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
title_short	Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
title_full	Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
title_fullStr	Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
title_full_unstemmed	Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
title_sort	selective degradation of pu.1 during autophagy represses the differentiation and antitumour activity of th9 cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ef5f37a4be9a43188f9b499831b2af44
work_keys_str_mv	AT thaizriveravargas selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells AT zhijiancai selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells AT yingyingshen selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells AT magaliedosset selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells AT isisbenoitlizon selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells AT tiffanymartin selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells AT aurelieroussey selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells AT richardaflavell selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells AT francoisghiringhelli selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells AT lionelapetoh selectivedegradationofpu1duringautophagyrepressesthedifferentiationandantitumouractivityofth9cells
_version_	1718386326159491072

Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

Ejemplares similares