Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives
Vascular dysfunction is a key hallmark of hypertension and related cardiovascular outcomes. As a well-known hemodynamic disease, hypertension is characterized by abnormal ventricular-vascular interactions. Complementing non-invasive systemic hemodynamics in hypertensive vascular risk assessment is o...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/ef60098f65d741dbb6823eef867471ce |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:ef60098f65d741dbb6823eef867471ce |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:ef60098f65d741dbb6823eef867471ce2021-11-22T06:18:50ZNon-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives2297-055X10.3389/fcvm.2021.744349https://doaj.org/article/ef60098f65d741dbb6823eef867471ce2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.744349/fullhttps://doaj.org/toc/2297-055XVascular dysfunction is a key hallmark of hypertension and related cardiovascular outcomes. As a well-known hemodynamic disease, hypertension is characterized by abnormal ventricular-vascular interactions. Complementing non-invasive systemic hemodynamics in hypertensive vascular risk assessment is of promising significance. We aimed to investigate the effects of abnormal hemodynamic states other than elevated blood pressure on vascular damage and establish a united index of systemic hemodynamics for generalized vascular risk evaluation. Non-invasive systemic hemodynamics, assessed by impedance cardiography, was compared among blood pressure stages. Vascular function was evaluated by flow-mediated dilation (FMD) and brachial-ankle pulse wave velocity (baPWV). Systemic hemodynamics was obtained from a total of 88 enrollees with a mean (±SD) systolic blood pressure 140 (±17) mm Hg, and aged 17 to 91 years. Both stroke systemic vascular resistance index and left stroke work index exhibited a significant alteration among blood pressure stages (p < 0.001; p = 0.01, respectively), whereas heterogeneous hemodynamic and vascular function subsets existed within similar blood pressure. In addition, blood pressure categories failed to recognize between-group differences in endothelial dysfunction (p = 0.88) and arterial stiffness (p = 0.26). An increase in myocardial contractility and a parallel decrease in afterload was associated with the decline of vascular dysfunction. Systemic Hemodynamic Index (SHI), as a surrogate marker, demonstrated a significantly negative correlation with vascular damage index (VDI, r = −0.49, p < 0.001). These findings illustrate that systemic hemodynamics underlying hypertensives provides more vascular information. The SHI/VDI score may be a feasible tool for cardiovascular function assessment.Jianning ZhangJianning ZhangJianning ZhangJiawen LiangJiawen LiangJiawen LiangXiaoyu ZhangXiaoyu ZhangXiaoyu ZhangChen SuChen SuChen SuJiang HeJiang HeJiang HeYumin QiuYumin QiuYumin QiuZhe ZhouZhe ZhouZhe ZhouZhichao WangZhichao WangZhichao WangBing DongBing DongBing DongQiang TuQiang TuQiang TuShiyue XuShiyue XuShiyue XuWenhao XiaWenhao XiaWenhao XiaJun TaoJun TaoJun TaoFrontiers Media S.A.articlehypertensionvascular functionimpedance cardiography (ICG)hemodynamicssurrogate biomarkerDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
hypertension vascular function impedance cardiography (ICG) hemodynamics surrogate biomarker Diseases of the circulatory (Cardiovascular) system RC666-701 |
| spellingShingle |
hypertension vascular function impedance cardiography (ICG) hemodynamics surrogate biomarker Diseases of the circulatory (Cardiovascular) system RC666-701 Jianning Zhang Jianning Zhang Jianning Zhang Jiawen Liang Jiawen Liang Jiawen Liang Xiaoyu Zhang Xiaoyu Zhang Xiaoyu Zhang Chen Su Chen Su Chen Su Jiang He Jiang He Jiang He Yumin Qiu Yumin Qiu Yumin Qiu Zhe Zhou Zhe Zhou Zhe Zhou Zhichao Wang Zhichao Wang Zhichao Wang Bing Dong Bing Dong Bing Dong Qiang Tu Qiang Tu Qiang Tu Shiyue Xu Shiyue Xu Shiyue Xu Wenhao Xia Wenhao Xia Wenhao Xia Jun Tao Jun Tao Jun Tao Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives |
| description |
Vascular dysfunction is a key hallmark of hypertension and related cardiovascular outcomes. As a well-known hemodynamic disease, hypertension is characterized by abnormal ventricular-vascular interactions. Complementing non-invasive systemic hemodynamics in hypertensive vascular risk assessment is of promising significance. We aimed to investigate the effects of abnormal hemodynamic states other than elevated blood pressure on vascular damage and establish a united index of systemic hemodynamics for generalized vascular risk evaluation. Non-invasive systemic hemodynamics, assessed by impedance cardiography, was compared among blood pressure stages. Vascular function was evaluated by flow-mediated dilation (FMD) and brachial-ankle pulse wave velocity (baPWV). Systemic hemodynamics was obtained from a total of 88 enrollees with a mean (±SD) systolic blood pressure 140 (±17) mm Hg, and aged 17 to 91 years. Both stroke systemic vascular resistance index and left stroke work index exhibited a significant alteration among blood pressure stages (p < 0.001; p = 0.01, respectively), whereas heterogeneous hemodynamic and vascular function subsets existed within similar blood pressure. In addition, blood pressure categories failed to recognize between-group differences in endothelial dysfunction (p = 0.88) and arterial stiffness (p = 0.26). An increase in myocardial contractility and a parallel decrease in afterload was associated with the decline of vascular dysfunction. Systemic Hemodynamic Index (SHI), as a surrogate marker, demonstrated a significantly negative correlation with vascular damage index (VDI, r = −0.49, p < 0.001). These findings illustrate that systemic hemodynamics underlying hypertensives provides more vascular information. The SHI/VDI score may be a feasible tool for cardiovascular function assessment. |
| format |
article |
| author |
Jianning Zhang Jianning Zhang Jianning Zhang Jiawen Liang Jiawen Liang Jiawen Liang Xiaoyu Zhang Xiaoyu Zhang Xiaoyu Zhang Chen Su Chen Su Chen Su Jiang He Jiang He Jiang He Yumin Qiu Yumin Qiu Yumin Qiu Zhe Zhou Zhe Zhou Zhe Zhou Zhichao Wang Zhichao Wang Zhichao Wang Bing Dong Bing Dong Bing Dong Qiang Tu Qiang Tu Qiang Tu Shiyue Xu Shiyue Xu Shiyue Xu Wenhao Xia Wenhao Xia Wenhao Xia Jun Tao Jun Tao Jun Tao |
| author_facet |
Jianning Zhang Jianning Zhang Jianning Zhang Jiawen Liang Jiawen Liang Jiawen Liang Xiaoyu Zhang Xiaoyu Zhang Xiaoyu Zhang Chen Su Chen Su Chen Su Jiang He Jiang He Jiang He Yumin Qiu Yumin Qiu Yumin Qiu Zhe Zhou Zhe Zhou Zhe Zhou Zhichao Wang Zhichao Wang Zhichao Wang Bing Dong Bing Dong Bing Dong Qiang Tu Qiang Tu Qiang Tu Shiyue Xu Shiyue Xu Shiyue Xu Wenhao Xia Wenhao Xia Wenhao Xia Jun Tao Jun Tao Jun Tao |
| author_sort |
Jianning Zhang |
| title |
Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives |
| title_short |
Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives |
| title_full |
Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives |
| title_fullStr |
Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives |
| title_full_unstemmed |
Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives |
| title_sort |
non-invasive systemic hemodynamic index in vascular risk stratification tailored for hypertensives |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/ef60098f65d741dbb6823eef867471ce |
| work_keys_str_mv |
AT jianningzhang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT jianningzhang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT jianningzhang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT jiawenliang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT jiawenliang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT jiawenliang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT xiaoyuzhang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT xiaoyuzhang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT xiaoyuzhang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT chensu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT chensu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT chensu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT jianghe noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT jianghe noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT jianghe noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT yuminqiu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT yuminqiu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT yuminqiu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT zhezhou noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT zhezhou noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT zhezhou noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT zhichaowang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT zhichaowang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT zhichaowang noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT bingdong noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT bingdong noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT bingdong noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT qiangtu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT qiangtu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT qiangtu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT shiyuexu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT shiyuexu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT shiyuexu noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT wenhaoxia noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT wenhaoxia noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT wenhaoxia noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT juntao noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT juntao noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives AT juntao noninvasivesystemichemodynamicindexinvascularriskstratificationtailoredforhypertensives |
| _version_ |
1718418137052872704 |