UFL1 promotes histone H4 ufmylation and ATM activation

Ufmylation is a ubiquitylation-like protein modification but only a few ufmylation substrates and functions have been discovered so far. Here, the authors demonstrate ufmylation of histone H4 upon DNA damage and show that this modification is involved in the amplification of ATM activation.

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Auteurs principaux:	Bo Qin, Jia Yu, Somaira Nowsheen, Minghui Wang, Xinyi Tu, Tongzheng Liu, Honglin Li, Liewei Wang, Zhenkun Lou
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ef61338d640d4b1f97d227ca1abf24ce
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id	oai:doaj.org-article:ef61338d640d4b1f97d227ca1abf24ce
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spelling	oai:doaj.org-article:ef61338d640d4b1f97d227ca1abf24ce2021-12-02T15:35:27ZUFL1 promotes histone H4 ufmylation and ATM activation10.1038/s41467-019-09175-02041-1723https://doaj.org/article/ef61338d640d4b1f97d227ca1abf24ce2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09175-0https://doaj.org/toc/2041-1723Ufmylation is a ubiquitylation-like protein modification but only a few ufmylation substrates and functions have been discovered so far. Here, the authors demonstrate ufmylation of histone H4 upon DNA damage and show that this modification is involved in the amplification of ATM activation.Bo QinJia YuSomaira NowsheenMinghui WangXinyi TuTongzheng LiuHonglin LiLiewei WangZhenkun LouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Qin Jia Yu Somaira Nowsheen Minghui Wang Xinyi Tu Tongzheng Liu Honglin Li Liewei Wang Zhenkun Lou UFL1 promotes histone H4 ufmylation and ATM activation
description	Ufmylation is a ubiquitylation-like protein modification but only a few ufmylation substrates and functions have been discovered so far. Here, the authors demonstrate ufmylation of histone H4 upon DNA damage and show that this modification is involved in the amplification of ATM activation.
format	article
author	Bo Qin Jia Yu Somaira Nowsheen Minghui Wang Xinyi Tu Tongzheng Liu Honglin Li Liewei Wang Zhenkun Lou
author_facet	Bo Qin Jia Yu Somaira Nowsheen Minghui Wang Xinyi Tu Tongzheng Liu Honglin Li Liewei Wang Zhenkun Lou
author_sort	Bo Qin
title	UFL1 promotes histone H4 ufmylation and ATM activation
title_short	UFL1 promotes histone H4 ufmylation and ATM activation
title_full	UFL1 promotes histone H4 ufmylation and ATM activation
title_fullStr	UFL1 promotes histone H4 ufmylation and ATM activation
title_full_unstemmed	UFL1 promotes histone H4 ufmylation and ATM activation
title_sort	ufl1 promotes histone h4 ufmylation and atm activation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ef61338d640d4b1f97d227ca1abf24ce
work_keys_str_mv	AT boqin ufl1promoteshistoneh4ufmylationandatmactivation AT jiayu ufl1promoteshistoneh4ufmylationandatmactivation AT somairanowsheen ufl1promoteshistoneh4ufmylationandatmactivation AT minghuiwang ufl1promoteshistoneh4ufmylationandatmactivation AT xinyitu ufl1promoteshistoneh4ufmylationandatmactivation AT tongzhengliu ufl1promoteshistoneh4ufmylationandatmactivation AT honglinli ufl1promoteshistoneh4ufmylationandatmactivation AT lieweiwang ufl1promoteshistoneh4ufmylationandatmactivation AT zhenkunlou ufl1promoteshistoneh4ufmylationandatmactivation
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UFL1 promotes histone H4 ufmylation and ATM activation

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