UFL1 promotes histone H4 ufmylation and ATM activation
Ufmylation is a ubiquitylation-like protein modification but only a few ufmylation substrates and functions have been discovered so far. Here, the authors demonstrate ufmylation of histone H4 upon DNA damage and show that this modification is involved in the amplification of ATM activation.
Saved in:
Main Authors: | Bo Qin, Jia Yu, Somaira Nowsheen, Minghui Wang, Xinyi Tu, Tongzheng Liu, Honglin Li, Liewei Wang, Zhenkun Lou |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2019
|
Subjects: | |
Online Access: | https://doaj.org/article/ef61338d640d4b1f97d227ca1abf24ce |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
by: Somaira Nowsheen, et al.
Published: (2018) -
CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
by: Tongzheng Liu, et al.
Published: (2017) -
The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair
by: Qin Zhou, et al.
Published: (2020) -
USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response
by: Yunhui Li, et al.
Published: (2017) -
Structure of the intact ATM/Tel1 kinase
by: Xuejuan Wang, et al.
Published: (2016)