SOX9: Advances in Gynecological Malignancies

Transcription factors of the SOX family were first discovered in mammals in 1990. The sex-determining region Y box 9 belongs to the SOX transcription factor family. It plays an important role in inducing tissue and cell morphogenesis, survival, and many developmental processes. Furthermore, it has b...

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Autores principales:	Huan Chen, Yujie He, Xiangping Wen, Shihong Shao, Yujie Liu, Jinjin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SOX9 ovarian cancer cervical cancer endometrial cancer uterine carcinosarcoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ef63c9a353de457caccc117b210c6382
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spelling	oai:doaj.org-article:ef63c9a353de457caccc117b210c63822021-11-22T06:26:56ZSOX9: Advances in Gynecological Malignancies2234-943X10.3389/fonc.2021.768264https://doaj.org/article/ef63c9a353de457caccc117b210c63822021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.768264/fullhttps://doaj.org/toc/2234-943XTranscription factors of the SOX family were first discovered in mammals in 1990. The sex-determining region Y box 9 belongs to the SOX transcription factor family. It plays an important role in inducing tissue and cell morphogenesis, survival, and many developmental processes. Furthermore, it has been shown to be an oncogene in many tumors. Gynecological malignancies are tumors that occur in the female reproductive system and seriously threaten the lives of patients. Common gynecological malignancies include ovarian cancer, cervical cancer, and endometrial cancer. So far, the molecular mechanisms related to the incidence and development of gynecological malignancies remain unclear. This makes it particularly important to discover their common causative molecule and thus provide an effective therapeutic target. In recent years, studies have found that multiple mechanisms are involved in regulating the expression of the sex-determining region Y box 9, leading to the occurrence and development of gynecological malignancies. In this review, we discuss the prognostic value of SOX9 expression and the potential of targeting SOX9 for gynecological malignancy treatment. We also discuss progress regarding the role of SOX9 in gynecological malignancy pathogenesis through its mediation of important mechanisms, including tumor initiation and proliferation, apoptosis, migration, invasion, chemoresistance, and stem cell maintenance.Huan ChenYujie HeXiangping WenShihong ShaoYujie LiuJinjin WangFrontiers Media S.A.articleSOX9ovarian cancercervical cancerendometrial canceruterine carcinosarcomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SOX9 ovarian cancer cervical cancer endometrial cancer uterine carcinosarcoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	SOX9 ovarian cancer cervical cancer endometrial cancer uterine carcinosarcoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Huan Chen Yujie He Xiangping Wen Shihong Shao Yujie Liu Jinjin Wang SOX9: Advances in Gynecological Malignancies
description	Transcription factors of the SOX family were first discovered in mammals in 1990. The sex-determining region Y box 9 belongs to the SOX transcription factor family. It plays an important role in inducing tissue and cell morphogenesis, survival, and many developmental processes. Furthermore, it has been shown to be an oncogene in many tumors. Gynecological malignancies are tumors that occur in the female reproductive system and seriously threaten the lives of patients. Common gynecological malignancies include ovarian cancer, cervical cancer, and endometrial cancer. So far, the molecular mechanisms related to the incidence and development of gynecological malignancies remain unclear. This makes it particularly important to discover their common causative molecule and thus provide an effective therapeutic target. In recent years, studies have found that multiple mechanisms are involved in regulating the expression of the sex-determining region Y box 9, leading to the occurrence and development of gynecological malignancies. In this review, we discuss the prognostic value of SOX9 expression and the potential of targeting SOX9 for gynecological malignancy treatment. We also discuss progress regarding the role of SOX9 in gynecological malignancy pathogenesis through its mediation of important mechanisms, including tumor initiation and proliferation, apoptosis, migration, invasion, chemoresistance, and stem cell maintenance.
format	article
author	Huan Chen Yujie He Xiangping Wen Shihong Shao Yujie Liu Jinjin Wang
author_facet	Huan Chen Yujie He Xiangping Wen Shihong Shao Yujie Liu Jinjin Wang
author_sort	Huan Chen
title	SOX9: Advances in Gynecological Malignancies
title_short	SOX9: Advances in Gynecological Malignancies
title_full	SOX9: Advances in Gynecological Malignancies
title_fullStr	SOX9: Advances in Gynecological Malignancies
title_full_unstemmed	SOX9: Advances in Gynecological Malignancies
title_sort	sox9: advances in gynecological malignancies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ef63c9a353de457caccc117b210c6382
work_keys_str_mv	AT huanchen sox9advancesingynecologicalmalignancies AT yujiehe sox9advancesingynecologicalmalignancies AT xiangpingwen sox9advancesingynecologicalmalignancies AT shihongshao sox9advancesingynecologicalmalignancies AT yujieliu sox9advancesingynecologicalmalignancies AT jinjinwang sox9advancesingynecologicalmalignancies
_version_	1718418137243713536

SOX9: Advances in Gynecological Malignancies

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