Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study
Abstract Stroke has a deleterious impact on quality of life. However, it is less well known if stroke lesions in different brain regions are associated with reduced quality of life (QoL). We therefore investigated this association by multivariate lesion-symptom mapping. We analyzed magnetic resonanc...
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2021
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oai:doaj.org-article:ef6466db0e0e48a889fbf97510930dbd2021-12-02T16:10:38ZInfluence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study10.1038/s41598-021-92865-x2045-2322https://doaj.org/article/ef6466db0e0e48a889fbf97510930dbd2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92865-xhttps://doaj.org/toc/2045-2322Abstract Stroke has a deleterious impact on quality of life. However, it is less well known if stroke lesions in different brain regions are associated with reduced quality of life (QoL). We therefore investigated this association by multivariate lesion-symptom mapping. We analyzed magnetic resonance imaging and clinical data from the WAKE-UP trial. European Quality of Life 5 Dimensions (EQ-5D) 3 level questionnaires were completed 90 days after stroke. Lesion symptom mapping was performed using a multivariate machine learning algorithm (support vector regression) based on stroke lesions 22–36 h after stroke. Brain regions with significant associations were explored in reference to white matter tracts. Of 503 randomized patients, 329 were included in the analysis (mean age 65.4 years, SD 11.5; median NIHSS = 6, IQR 4–9; median EQ-5D score 90 days after stroke 1, IQR 0–4, median lesion volume 3.3 ml, IQR 1.1–16.9 ml). After controlling for lesion volume, significant associations between lesions and EQ-5D score were detected for the right putamen, and internal capsules of both hemispheres. Multivariate lesion inference analysis revealed an association between injuries of the cortico-spinal tracts with worse self-reported quality of life 90 days after stroke in comparably small stroke lesions, extending previous reports of the association of striato-capsular lesions with worse functional outcome. Our findings are of value to identify patients at risk of impaired QoL after stroke.Alina KönigsbergAndrew T. DeMarcoCarola MayerAnke WoutersEckhard SchlemmMartin EbingerTae-Hee ChoMatthias EndresJochen B. FiebachJens FiehlerIvana GalinovicJosep PuigVincent ThijsRobin LemmensKeith W. MuirNorbert NighoghossianSalvador PedrazaClaus Z. SimonsenChristian GerloffGötz ThomallaBastian ChengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q Alina Königsberg Andrew T. DeMarco Carola Mayer Anke Wouters Eckhard Schlemm Martin Ebinger Tae-Hee Cho Matthias Endres Jochen B. Fiebach Jens Fiehler Ivana Galinovic Josep Puig Vincent Thijs Robin Lemmens Keith W. Muir Norbert Nighoghossian Salvador Pedraza Claus Z. Simonsen Christian Gerloff Götz Thomalla Bastian Cheng Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study |
| description |
Abstract Stroke has a deleterious impact on quality of life. However, it is less well known if stroke lesions in different brain regions are associated with reduced quality of life (QoL). We therefore investigated this association by multivariate lesion-symptom mapping. We analyzed magnetic resonance imaging and clinical data from the WAKE-UP trial. European Quality of Life 5 Dimensions (EQ-5D) 3 level questionnaires were completed 90 days after stroke. Lesion symptom mapping was performed using a multivariate machine learning algorithm (support vector regression) based on stroke lesions 22–36 h after stroke. Brain regions with significant associations were explored in reference to white matter tracts. Of 503 randomized patients, 329 were included in the analysis (mean age 65.4 years, SD 11.5; median NIHSS = 6, IQR 4–9; median EQ-5D score 90 days after stroke 1, IQR 0–4, median lesion volume 3.3 ml, IQR 1.1–16.9 ml). After controlling for lesion volume, significant associations between lesions and EQ-5D score were detected for the right putamen, and internal capsules of both hemispheres. Multivariate lesion inference analysis revealed an association between injuries of the cortico-spinal tracts with worse self-reported quality of life 90 days after stroke in comparably small stroke lesions, extending previous reports of the association of striato-capsular lesions with worse functional outcome. Our findings are of value to identify patients at risk of impaired QoL after stroke. |
| format |
article |
| author |
Alina Königsberg Andrew T. DeMarco Carola Mayer Anke Wouters Eckhard Schlemm Martin Ebinger Tae-Hee Cho Matthias Endres Jochen B. Fiebach Jens Fiehler Ivana Galinovic Josep Puig Vincent Thijs Robin Lemmens Keith W. Muir Norbert Nighoghossian Salvador Pedraza Claus Z. Simonsen Christian Gerloff Götz Thomalla Bastian Cheng |
| author_facet |
Alina Königsberg Andrew T. DeMarco Carola Mayer Anke Wouters Eckhard Schlemm Martin Ebinger Tae-Hee Cho Matthias Endres Jochen B. Fiebach Jens Fiehler Ivana Galinovic Josep Puig Vincent Thijs Robin Lemmens Keith W. Muir Norbert Nighoghossian Salvador Pedraza Claus Z. Simonsen Christian Gerloff Götz Thomalla Bastian Cheng |
| author_sort |
Alina Königsberg |
| title |
Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study |
| title_short |
Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study |
| title_full |
Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study |
| title_fullStr |
Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study |
| title_full_unstemmed |
Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study |
| title_sort |
influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ef6466db0e0e48a889fbf97510930dbd |
| work_keys_str_mv |
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