Aerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide Thailand healthcare database

Abstract Occupational and environmental associations with systemic sclerosis (SSc) have been confirmed; however, the association between aerosol components and mortality is uncertain. The study aimed to define the association between aerosol components and hospital mortality among Thai SSc patients....

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Autores principales:	Chingching Foocharoen, Udomlack Peansukwech, Patnarin Pongkulkiat, Ajanee Mahakkanukrauh, Siraphop Suwannaroj
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef677d71cb4544b8a5fece001b99704a
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spelling	oai:doaj.org-article:ef677d71cb4544b8a5fece001b99704a2021-12-02T15:51:12ZAerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide Thailand healthcare database10.1038/s41598-021-87114-02045-2322https://doaj.org/article/ef677d71cb4544b8a5fece001b99704a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87114-0https://doaj.org/toc/2045-2322Abstract Occupational and environmental associations with systemic sclerosis (SSc) have been confirmed; however, the association between aerosol components and mortality is uncertain. The study aimed to define the association between aerosol components and hospital mortality among Thai SSc patients. A study was conducted using a national database of patients covered by the National Health Security Office, hospitalised between 2014 and 2018. Data included all patients over 18 having a primary diagnosis of SSc (ICD-10: M34). Spatial resources used map information based on GPS coordinates of Thailand. Aerosol components—including organic carbon, black carbon, dust particulate matter diameter < 2.5 µm (PM2.5), and sulfate—were assessed using the NASA satellite MERRA-2 Model M2TMNXFLX v5.12.4. Spatial modelling with R Package Integrated Nested Laplace Approximation (R-INLA) was used to analyse the association between the incidence of mortality and the 5-year accumulation of each aerosol component adjusted by age, sex, and comorbid diseases. The study included 2,094 SSc patients with 3,684 admissions. Most (63.8%) were female. During admission, 1,276 cases died. R-INLA analysis indicated an increase of 1 µg/m3 of dust PM2.5 was associated with a respective increase in the risk of overall mortality and death due to pneumonia of 96% and 79%. An increase of 1 µg/m3 of dust PM2.5 resulted in 1.17, 1.18, 1.64, and 2.15 times greater risk of mortality due to pulmonary fibrosis, cardiac involvement, renal involvement, and cancer, respectively. Aerosol components—particularly dust PM2.5 exposures—increased the risk of overall, cardio-pulmonary-renal, and cancer mortality among SSc patients.Chingching FoocharoenUdomlack PeansukwechPatnarin PongkulkiatAjanee MahakkanukrauhSiraphop SuwannarojNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chingching Foocharoen Udomlack Peansukwech Patnarin Pongkulkiat Ajanee Mahakkanukrauh Siraphop Suwannaroj Aerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide Thailand healthcare database
description	Abstract Occupational and environmental associations with systemic sclerosis (SSc) have been confirmed; however, the association between aerosol components and mortality is uncertain. The study aimed to define the association between aerosol components and hospital mortality among Thai SSc patients. A study was conducted using a national database of patients covered by the National Health Security Office, hospitalised between 2014 and 2018. Data included all patients over 18 having a primary diagnosis of SSc (ICD-10: M34). Spatial resources used map information based on GPS coordinates of Thailand. Aerosol components—including organic carbon, black carbon, dust particulate matter diameter < 2.5 µm (PM2.5), and sulfate—were assessed using the NASA satellite MERRA-2 Model M2TMNXFLX v5.12.4. Spatial modelling with R Package Integrated Nested Laplace Approximation (R-INLA) was used to analyse the association between the incidence of mortality and the 5-year accumulation of each aerosol component adjusted by age, sex, and comorbid diseases. The study included 2,094 SSc patients with 3,684 admissions. Most (63.8%) were female. During admission, 1,276 cases died. R-INLA analysis indicated an increase of 1 µg/m3 of dust PM2.5 was associated with a respective increase in the risk of overall mortality and death due to pneumonia of 96% and 79%. An increase of 1 µg/m3 of dust PM2.5 resulted in 1.17, 1.18, 1.64, and 2.15 times greater risk of mortality due to pulmonary fibrosis, cardiac involvement, renal involvement, and cancer, respectively. Aerosol components—particularly dust PM2.5 exposures—increased the risk of overall, cardio-pulmonary-renal, and cancer mortality among SSc patients.
format	article
author	Chingching Foocharoen Udomlack Peansukwech Patnarin Pongkulkiat Ajanee Mahakkanukrauh Siraphop Suwannaroj
author_facet	Chingching Foocharoen Udomlack Peansukwech Patnarin Pongkulkiat Ajanee Mahakkanukrauh Siraphop Suwannaroj
author_sort	Chingching Foocharoen
title	Aerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide Thailand healthcare database
title_short	Aerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide Thailand healthcare database
title_full	Aerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide Thailand healthcare database
title_fullStr	Aerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide Thailand healthcare database
title_full_unstemmed	Aerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide Thailand healthcare database
title_sort	aerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide thailand healthcare database
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef677d71cb4544b8a5fece001b99704a
work_keys_str_mv	AT chingchingfoocharoen aerosolcomponentsassociatedwithhospitalmortalityinsystemicsclerosisananalysisfromanationwidethailandhealthcaredatabase AT udomlackpeansukwech aerosolcomponentsassociatedwithhospitalmortalityinsystemicsclerosisananalysisfromanationwidethailandhealthcaredatabase AT patnarinpongkulkiat aerosolcomponentsassociatedwithhospitalmortalityinsystemicsclerosisananalysisfromanationwidethailandhealthcaredatabase AT ajaneemahakkanukrauh aerosolcomponentsassociatedwithhospitalmortalityinsystemicsclerosisananalysisfromanationwidethailandhealthcaredatabase AT siraphopsuwannaroj aerosolcomponentsassociatedwithhospitalmortalityinsystemicsclerosisananalysisfromanationwidethailandhealthcaredatabase
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Aerosol components associated with hospital mortality in systemic sclerosis: an analysis from a nationwide Thailand healthcare database

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