Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

High cholesterol has been associated with increased risk of cancer but the underlying mechanism is not completely understood. Here, the authors show that a cholesterol metabolite induces metabolic reprogramming that generates ferroptosis-resistant cancer cells leading to increased tumour growth and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wen Liu, Binita Chakraborty, Rachid Safi, Dmitri Kazmin, Ching-yi Chang, Donald P. McDonnell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef682fd9b47c4243a18058a5dedb403b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ef682fd9b47c4243a18058a5dedb403b
record_format	dspace
spelling	oai:doaj.org-article:ef682fd9b47c4243a18058a5dedb403b2021-12-02T16:34:55ZDysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer10.1038/s41467-021-25354-42041-1723https://doaj.org/article/ef682fd9b47c4243a18058a5dedb403b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25354-4https://doaj.org/toc/2041-1723High cholesterol has been associated with increased risk of cancer but the underlying mechanism is not completely understood. Here, the authors show that a cholesterol metabolite induces metabolic reprogramming that generates ferroptosis-resistant cancer cells leading to increased tumour growth and metastasis.Wen LiuBinita ChakrabortyRachid SafiDmitri KazminChing-yi ChangDonald P. McDonnellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen Liu Binita Chakraborty Rachid Safi Dmitri Kazmin Ching-yi Chang Donald P. McDonnell Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
description	High cholesterol has been associated with increased risk of cancer but the underlying mechanism is not completely understood. Here, the authors show that a cholesterol metabolite induces metabolic reprogramming that generates ferroptosis-resistant cancer cells leading to increased tumour growth and metastasis.
format	article
author	Wen Liu Binita Chakraborty Rachid Safi Dmitri Kazmin Ching-yi Chang Donald P. McDonnell
author_facet	Wen Liu Binita Chakraborty Rachid Safi Dmitri Kazmin Ching-yi Chang Donald P. McDonnell
author_sort	Wen Liu
title	Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
title_short	Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
title_full	Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
title_fullStr	Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
title_full_unstemmed	Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
title_sort	dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef682fd9b47c4243a18058a5dedb403b
work_keys_str_mv	AT wenliu dysregulatedcholesterolhomeostasisresultsinresistancetoferroptosisincreasingtumorigenicityandmetastasisincancer AT binitachakraborty dysregulatedcholesterolhomeostasisresultsinresistancetoferroptosisincreasingtumorigenicityandmetastasisincancer AT rachidsafi dysregulatedcholesterolhomeostasisresultsinresistancetoferroptosisincreasingtumorigenicityandmetastasisincancer AT dmitrikazmin dysregulatedcholesterolhomeostasisresultsinresistancetoferroptosisincreasingtumorigenicityandmetastasisincancer AT chingyichang dysregulatedcholesterolhomeostasisresultsinresistancetoferroptosisincreasingtumorigenicityandmetastasisincancer AT donaldpmcdonnell dysregulatedcholesterolhomeostasisresultsinresistancetoferroptosisincreasingtumorigenicityandmetastasisincancer
_version_	1718383788052971520

Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

Ejemplares similares