Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

High cholesterol has been associated with increased risk of cancer but the underlying mechanism is not completely understood. Here, the authors show that a cholesterol metabolite induces metabolic reprogramming that generates ferroptosis-resistant cancer cells leading to increased tumour growth and...

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Autores principales: Wen Liu, Binita Chakraborty, Rachid Safi, Dmitri Kazmin, Ching-yi Chang, Donald P. McDonnell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ef682fd9b47c4243a18058a5dedb403b
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