Impact of CBCT frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy

Abstract The current study aims to assess the effect of cone beam computed tomography (CBCT) frequency during adjuvant breast cancer radiotherapy with simultaneous integrated boost (SIB) on target volume coverage and dose to the organs at risk (OAR). 50 breast cancer patients receiving either non-hy...

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Autores principales:	Kai J. Borm, Yannis Junker, Mathias Düsberg, Michal Devečka, Stefan Münch, Hendrik Dapper, Markus Oechsner, Stephanie E. Combs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef6e12c0c0414050bba7dced9aaac8d2
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spelling	oai:doaj.org-article:ef6e12c0c0414050bba7dced9aaac8d22021-12-02T16:38:49ZImpact of CBCT frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy10.1038/s41598-021-96836-02045-2322https://doaj.org/article/ef6e12c0c0414050bba7dced9aaac8d22021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96836-0https://doaj.org/toc/2045-2322Abstract The current study aims to assess the effect of cone beam computed tomography (CBCT) frequency during adjuvant breast cancer radiotherapy with simultaneous integrated boost (SIB) on target volume coverage and dose to the organs at risk (OAR). 50 breast cancer patients receiving either non-hypofractionated or hypofractionated radiotherapy after lumpectomy including a SIB to the tumor bed were selected for this study. All patients were treated in volumetric modulated arc therapy (VMAT) technique and underwent daily CBCT imaging. In order to estimate the delivered dose during the treatment, the applied fraction doses were recalculated on daily CBCT scans and accumulated using deformable image registration. Based on a total of 2440 dose recalculations, dose coverage in the clinical target volumes (CTV) and OAR was compared depending on the CBCT frequency. The estimated delivered dose (V95%) for breast-CTV and SIB-CTV was significantly lower than the planned dose distribution, irrespective of the CBCT-frequency. Between daily CBCT and CBCT on alternate days, no significant dose differences were found regarding V95% for both, breast-CTV and SIB-CTV. Dose distribution in the OAR was similar for both imaging protocols. Weekly CBCT though led to a significant decrease in dose coverage compared to daily CBCT and a small but significant dose increase in most OAR. Daily CBCT imaging might not be necessary to ensure adequate dose coverage in the target volumes while efficiently sparing the OAR during adjuvant breast cancer radiotherapy with SIB.Kai J. BormYannis JunkerMathias DüsbergMichal DevečkaStefan MünchHendrik DapperMarkus OechsnerStephanie E. CombsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kai J. Borm Yannis Junker Mathias Düsberg Michal Devečka Stefan Münch Hendrik Dapper Markus Oechsner Stephanie E. Combs Impact of CBCT frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy
description	Abstract The current study aims to assess the effect of cone beam computed tomography (CBCT) frequency during adjuvant breast cancer radiotherapy with simultaneous integrated boost (SIB) on target volume coverage and dose to the organs at risk (OAR). 50 breast cancer patients receiving either non-hypofractionated or hypofractionated radiotherapy after lumpectomy including a SIB to the tumor bed were selected for this study. All patients were treated in volumetric modulated arc therapy (VMAT) technique and underwent daily CBCT imaging. In order to estimate the delivered dose during the treatment, the applied fraction doses were recalculated on daily CBCT scans and accumulated using deformable image registration. Based on a total of 2440 dose recalculations, dose coverage in the clinical target volumes (CTV) and OAR was compared depending on the CBCT frequency. The estimated delivered dose (V95%) for breast-CTV and SIB-CTV was significantly lower than the planned dose distribution, irrespective of the CBCT-frequency. Between daily CBCT and CBCT on alternate days, no significant dose differences were found regarding V95% for both, breast-CTV and SIB-CTV. Dose distribution in the OAR was similar for both imaging protocols. Weekly CBCT though led to a significant decrease in dose coverage compared to daily CBCT and a small but significant dose increase in most OAR. Daily CBCT imaging might not be necessary to ensure adequate dose coverage in the target volumes while efficiently sparing the OAR during adjuvant breast cancer radiotherapy with SIB.
format	article
author	Kai J. Borm Yannis Junker Mathias Düsberg Michal Devečka Stefan Münch Hendrik Dapper Markus Oechsner Stephanie E. Combs
author_facet	Kai J. Borm Yannis Junker Mathias Düsberg Michal Devečka Stefan Münch Hendrik Dapper Markus Oechsner Stephanie E. Combs
author_sort	Kai J. Borm
title	Impact of CBCT frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy
title_short	Impact of CBCT frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy
title_full	Impact of CBCT frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy
title_fullStr	Impact of CBCT frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy
title_full_unstemmed	Impact of CBCT frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy
title_sort	impact of cbct frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef6e12c0c0414050bba7dced9aaac8d2
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Impact of CBCT frequency on target coverage and dose to the organs at risk in adjuvant breast cancer radiotherapy

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