Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation

The relative abundance of specific tRNA can impact protein production rate, folding, and messenger RNA stability. Here the authors describe QuantM-tRNA seq — a method to monitor tRNA abundance and sequence variants — and uncover distinctions in isodecoder expression between tissues that are independ...

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Autores principales:	Otis Pinkard, Sean McFarland, Thomas Sweet, Jeff Coller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef707c41b35c4390a78986746ab795bd
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spelling	oai:doaj.org-article:ef707c41b35c4390a78986746ab795bd2021-12-02T18:51:02ZQuantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation10.1038/s41467-020-17879-x2041-1723https://doaj.org/article/ef707c41b35c4390a78986746ab795bd2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17879-xhttps://doaj.org/toc/2041-1723The relative abundance of specific tRNA can impact protein production rate, folding, and messenger RNA stability. Here the authors describe QuantM-tRNA seq — a method to monitor tRNA abundance and sequence variants — and uncover distinctions in isodecoder expression between tissues that are independent of the anticodon pool of each tRNA family.Otis PinkardSean McFarlandThomas SweetJeff CollerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Otis Pinkard Sean McFarland Thomas Sweet Jeff Coller Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
description	The relative abundance of specific tRNA can impact protein production rate, folding, and messenger RNA stability. Here the authors describe QuantM-tRNA seq — a method to monitor tRNA abundance and sequence variants — and uncover distinctions in isodecoder expression between tissues that are independent of the anticodon pool of each tRNA family.
format	article
author	Otis Pinkard Sean McFarland Thomas Sweet Jeff Coller
author_facet	Otis Pinkard Sean McFarland Thomas Sweet Jeff Coller
author_sort	Otis Pinkard
title	Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
title_short	Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
title_full	Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
title_fullStr	Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
title_full_unstemmed	Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
title_sort	quantitative trna-sequencing uncovers metazoan tissue-specific trna regulation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ef707c41b35c4390a78986746ab795bd
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Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation

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