SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

Splicing factor PTBP1 is reported to promote oncogenic functions in glioblastoma (GBM). Here the authors show splicing factor SON upregulates PTBP1 expression while supresses its paralog PTBP2 through alternative splicing and the inhibition of SON reduces GBM stemness and growth.

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Autores principales:	Jung-Hyun Kim, Kyuho Jeong, Jianfeng Li, James M. Murphy, Lana Vukadin, Joshua K. Stone, Alexander Richard, Johnny Tran, G. Yancey Gillespie, Erik K. Flemington, Robert W. Sobol, Ssang-Teak Steve Lim, Eun-Young Erin Ahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef70cfa927e24e59962a148691be73fd
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spelling	oai:doaj.org-article:ef70cfa927e24e59962a148691be73fd2021-12-02T17:27:20ZSON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity10.1038/s41467-021-25892-x2041-1723https://doaj.org/article/ef70cfa927e24e59962a148691be73fd2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25892-xhttps://doaj.org/toc/2041-1723Splicing factor PTBP1 is reported to promote oncogenic functions in glioblastoma (GBM). Here the authors show splicing factor SON upregulates PTBP1 expression while supresses its paralog PTBP2 through alternative splicing and the inhibition of SON reduces GBM stemness and growth.Jung-Hyun KimKyuho JeongJianfeng LiJames M. MurphyLana VukadinJoshua K. StoneAlexander RichardJohnny TranG. Yancey GillespieErik K. FlemingtonRobert W. SobolSsang-Teak Steve LimEun-Young Erin AhnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-Hyun Kim Kyuho Jeong Jianfeng Li James M. Murphy Lana Vukadin Joshua K. Stone Alexander Richard Johnny Tran G. Yancey Gillespie Erik K. Flemington Robert W. Sobol Ssang-Teak Steve Lim Eun-Young Erin Ahn SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity
description	Splicing factor PTBP1 is reported to promote oncogenic functions in glioblastoma (GBM). Here the authors show splicing factor SON upregulates PTBP1 expression while supresses its paralog PTBP2 through alternative splicing and the inhibition of SON reduces GBM stemness and growth.
format	article
author	Jung-Hyun Kim Kyuho Jeong Jianfeng Li James M. Murphy Lana Vukadin Joshua K. Stone Alexander Richard Johnny Tran G. Yancey Gillespie Erik K. Flemington Robert W. Sobol Ssang-Teak Steve Lim Eun-Young Erin Ahn
author_facet	Jung-Hyun Kim Kyuho Jeong Jianfeng Li James M. Murphy Lana Vukadin Joshua K. Stone Alexander Richard Johnny Tran G. Yancey Gillespie Erik K. Flemington Robert W. Sobol Ssang-Teak Steve Lim Eun-Young Erin Ahn
author_sort	Jung-Hyun Kim
title	SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity
title_short	SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity
title_full	SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity
title_fullStr	SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity
title_full_unstemmed	SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity
title_sort	son drives oncogenic rna splicing in glioblastoma by regulating ptbp1/ptbp2 switching and rbfox2 activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef70cfa927e24e59962a148691be73fd
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SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

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