Stem cell technology for tendon regeneration: current status, challenges, and future research directions

Pauline Po Yee Lui Headquarter, Hospital Authority, Hong Kong SAR, People's Republic of China Abstract: Tendon injuries are a common cause of physical disability. They present a clinical challenge to orthopedic surgeons because injured tendons respond poorly to current treatments without ti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Lui PP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	stem cells tendon repair tendon tissue engineering tendon injuries Cytology QH573-671
Acceso en línea:	https://doaj.org/article/ef74aae9eb5247258a4735762f385e91
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ef74aae9eb5247258a4735762f385e91
record_format	dspace
spelling	oai:doaj.org-article:ef74aae9eb5247258a4735762f385e912021-12-02T05:07:20ZStem cell technology for tendon regeneration: current status, challenges, and future research directions1178-6957https://doaj.org/article/ef74aae9eb5247258a4735762f385e912015-12-01T00:00:00Zhttps://www.dovepress.com/stem-cell-technology-for-tendon-regeneration-current-status-challenges-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Pauline Po Yee Lui Headquarter, Hospital Authority, Hong Kong SAR, People's Republic of China Abstract: Tendon injuries are a common cause of physical disability. They present a clinical challenge to orthopedic surgeons because injured tendons respond poorly to current treatments without tissue regeneration and the time required for rehabilitation is long. New treatment options are required. Stem cell-based therapies offer great potential to promote tendon regeneration due to their high proliferative, synthetic, and immunomodulatory activities as well as their potential to differentiate to the target cell types and undergo genetic modification. In this review, I first recapped the challenges of tendon repair by reviewing the anatomy of tendon. Next, I discussed the advantages and limitations of using different types of stem cells compared to terminally differentiated cells for tendon tissue engineering. The safety and efficacy of application of stem cells and their modified counterparts for tendon tissue engineering were then summarized after a systematic literature search in PubMed. The challenges and future research directions to enhance, optimize, and standardize stem cell-based therapies for augmenting tendon repair were then discussed. Keywords: stem cells, tendon repair, tendon tissue engineering, tendon injuriesLui PPDove Medical Pressarticlestem cellstendon repairtendon tissue engineeringtendon injuriesCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2015, Iss Issue 1, Pp 163-174 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cells tendon repair tendon tissue engineering tendon injuries Cytology QH573-671
spellingShingle	stem cells tendon repair tendon tissue engineering tendon injuries Cytology QH573-671 Lui PP Stem cell technology for tendon regeneration: current status, challenges, and future research directions
description	Pauline Po Yee Lui Headquarter, Hospital Authority, Hong Kong SAR, People's Republic of China Abstract: Tendon injuries are a common cause of physical disability. They present a clinical challenge to orthopedic surgeons because injured tendons respond poorly to current treatments without tissue regeneration and the time required for rehabilitation is long. New treatment options are required. Stem cell-based therapies offer great potential to promote tendon regeneration due to their high proliferative, synthetic, and immunomodulatory activities as well as their potential to differentiate to the target cell types and undergo genetic modification. In this review, I first recapped the challenges of tendon repair by reviewing the anatomy of tendon. Next, I discussed the advantages and limitations of using different types of stem cells compared to terminally differentiated cells for tendon tissue engineering. The safety and efficacy of application of stem cells and their modified counterparts for tendon tissue engineering were then summarized after a systematic literature search in PubMed. The challenges and future research directions to enhance, optimize, and standardize stem cell-based therapies for augmenting tendon repair were then discussed. Keywords: stem cells, tendon repair, tendon tissue engineering, tendon injuries
format	article
author	Lui PP
author_facet	Lui PP
author_sort	Lui PP
title	Stem cell technology for tendon regeneration: current status, challenges, and future research directions
title_short	Stem cell technology for tendon regeneration: current status, challenges, and future research directions
title_full	Stem cell technology for tendon regeneration: current status, challenges, and future research directions
title_fullStr	Stem cell technology for tendon regeneration: current status, challenges, and future research directions
title_full_unstemmed	Stem cell technology for tendon regeneration: current status, challenges, and future research directions
title_sort	stem cell technology for tendon regeneration: current status, challenges, and future research directions
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/ef74aae9eb5247258a4735762f385e91
work_keys_str_mv	AT luipp stemcelltechnologyfortendonregenerationcurrentstatuschallengesandfutureresearchdirections
_version_	1718400626327552000

Stem cell technology for tendon regeneration: current status, challenges, and future research directions

Ejemplares similares