Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain

Abstract Electrical stimulation of the cerebral cortex (ESCC) has been used to treat intractable neuropathic pain for nearly two decades, however, no standardized approach for this technique has been developed. In order to optimize targeting and validate the effect of ESCC before placing the permane...

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Autores principales:	Igor Lavrov, Timur Latypov, Elvira Mukhametova, Brian Lundstrom, Paola Sandroni, Kendall Lee, Bryan Klassen, Matt Stead
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef761947a15948ca9d7acc16fa37d4c6
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spelling	oai:doaj.org-article:ef761947a15948ca9d7acc16fa37d4c62021-12-02T17:39:57ZPre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain10.1038/s41598-021-91872-22045-2322https://doaj.org/article/ef761947a15948ca9d7acc16fa37d4c62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91872-2https://doaj.org/toc/2045-2322Abstract Electrical stimulation of the cerebral cortex (ESCC) has been used to treat intractable neuropathic pain for nearly two decades, however, no standardized approach for this technique has been developed. In order to optimize targeting and validate the effect of ESCC before placing the permanent grid, we introduced initial assessment with trial stimulation, using a temporary grid of subdural electrodes. In this retrospective study we evaluate the role of electrode location on cerebral cortex in control of neuropathic pain and the role of trial stimulation in target-optimization for ESCC. Location of the temporary grid electrodes and location of permanent electrodes were evaluated in correlation with the long-term efficacy of ESCC. The results of this study demonstrate that the long-term effect of subdural pre-motor cortex stimulation is at least the same or higher compare to effect of subdural motor or combined pre-motor and motor cortex stimulation. These results also demonstrate that the initial trial stimulation helps to optimize permanent electrode positions in relation to the optimal functional target that is critical in cases when brain shift is expected. Proposed methodology and novel results open a new direction for development of neuromodulation techniques to control chronic neuropathic pain.Igor LavrovTimur LatypovElvira MukhametovaBrian LundstromPaola SandroniKendall LeeBryan KlassenMatt SteadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Igor Lavrov Timur Latypov Elvira Mukhametova Brian Lundstrom Paola Sandroni Kendall Lee Bryan Klassen Matt Stead Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain
description	Abstract Electrical stimulation of the cerebral cortex (ESCC) has been used to treat intractable neuropathic pain for nearly two decades, however, no standardized approach for this technique has been developed. In order to optimize targeting and validate the effect of ESCC before placing the permanent grid, we introduced initial assessment with trial stimulation, using a temporary grid of subdural electrodes. In this retrospective study we evaluate the role of electrode location on cerebral cortex in control of neuropathic pain and the role of trial stimulation in target-optimization for ESCC. Location of the temporary grid electrodes and location of permanent electrodes were evaluated in correlation with the long-term efficacy of ESCC. The results of this study demonstrate that the long-term effect of subdural pre-motor cortex stimulation is at least the same or higher compare to effect of subdural motor or combined pre-motor and motor cortex stimulation. These results also demonstrate that the initial trial stimulation helps to optimize permanent electrode positions in relation to the optimal functional target that is critical in cases when brain shift is expected. Proposed methodology and novel results open a new direction for development of neuromodulation techniques to control chronic neuropathic pain.
format	article
author	Igor Lavrov Timur Latypov Elvira Mukhametova Brian Lundstrom Paola Sandroni Kendall Lee Bryan Klassen Matt Stead
author_facet	Igor Lavrov Timur Latypov Elvira Mukhametova Brian Lundstrom Paola Sandroni Kendall Lee Bryan Klassen Matt Stead
author_sort	Igor Lavrov
title	Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain
title_short	Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain
title_full	Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain
title_fullStr	Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain
title_full_unstemmed	Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain
title_sort	pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef761947a15948ca9d7acc16fa37d4c6
work_keys_str_mv	AT igorlavrov premotorversusmotorcerebralcortexneuromodulationforchronicneuropathicpain AT timurlatypov premotorversusmotorcerebralcortexneuromodulationforchronicneuropathicpain AT elviramukhametova premotorversusmotorcerebralcortexneuromodulationforchronicneuropathicpain AT brianlundstrom premotorversusmotorcerebralcortexneuromodulationforchronicneuropathicpain AT paolasandroni premotorversusmotorcerebralcortexneuromodulationforchronicneuropathicpain AT kendalllee premotorversusmotorcerebralcortexneuromodulationforchronicneuropathicpain AT bryanklassen premotorversusmotorcerebralcortexneuromodulationforchronicneuropathicpain AT mattstead premotorversusmotorcerebralcortexneuromodulationforchronicneuropathicpain
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Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain

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