Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides

Acyclic quaternary stereocenters are widely present in a series of biologically active natural products and pharmaceuticals. Here the authors show an efficient chiral phosphoric acid catalyzed direct asymmetric addition of α-alkynyl acyclic ketones with allenamides to produce acyclic all-carbon quat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiawen Wang, Faqian He, Xiaoyu Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef7661bf06504799be617021be5acbed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ef7661bf06504799be617021be5acbed
record_format	dspace
spelling	oai:doaj.org-article:ef7661bf06504799be617021be5acbed2021-11-21T12:34:34ZAsymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides10.1038/s41467-021-27028-72041-1723https://doaj.org/article/ef7661bf06504799be617021be5acbed2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27028-7https://doaj.org/toc/2041-1723Acyclic quaternary stereocenters are widely present in a series of biologically active natural products and pharmaceuticals. Here the authors show an efficient chiral phosphoric acid catalyzed direct asymmetric addition of α-alkynyl acyclic ketones with allenamides to produce acyclic all-carbon quaternary stereocenters with excellent regioselectivities and high enantioselectivities:Jiawen WangFaqian HeXiaoyu YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiawen Wang Faqian He Xiaoyu Yang Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
description	Acyclic quaternary stereocenters are widely present in a series of biologically active natural products and pharmaceuticals. Here the authors show an efficient chiral phosphoric acid catalyzed direct asymmetric addition of α-alkynyl acyclic ketones with allenamides to produce acyclic all-carbon quaternary stereocenters with excellent regioselectivities and high enantioselectivities:
format	article
author	Jiawen Wang Faqian He Xiaoyu Yang
author_facet	Jiawen Wang Faqian He Xiaoyu Yang
author_sort	Jiawen Wang
title	Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
title_short	Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
title_full	Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
title_fullStr	Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
title_full_unstemmed	Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
title_sort	asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef7661bf06504799be617021be5acbed
work_keys_str_mv	AT jiawenwang asymmetricconstructionofacyclicquaternarystereocentersviadirectenantioselectiveadditionsofaalkynylketonestoallenamides AT faqianhe asymmetricconstructionofacyclicquaternarystereocentersviadirectenantioselectiveadditionsofaalkynylketonestoallenamides AT xiaoyuyang asymmetricconstructionofacyclicquaternarystereocentersviadirectenantioselectiveadditionsofaalkynylketonestoallenamides
_version_	1718418921517744128

Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides

Ejemplares similares