Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides
Acyclic quaternary stereocenters are widely present in a series of biologically active natural products and pharmaceuticals. Here the authors show an efficient chiral phosphoric acid catalyzed direct asymmetric addition of α-alkynyl acyclic ketones with allenamides to produce acyclic all-carbon quat...
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| Main Authors: | , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/ef7661bf06504799be617021be5acbed |
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