Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism

The neuroimaging literature indicates that brain structure and function both deteriorate with diabetes, but information on sexual dimorphism in diabetes-related brain alterations is limited. This study aimed to ascertain whether brain metabolism is influenced by sex in an animal model of diabetes. E...

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Autores principales:	Chun-Yi Wu, Yu-Hsin Lin, Hsin-Hua Hsieh, Jia-Jia Lin, Shin-Lei Peng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	positron emission tomography (PET) streptozotocin (STZ) <sup>18</sup>F-FDG hyperglycemia sexual dimorphism diabetes Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ef7727a7311244f99efa5023622673d3
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spelling	oai:doaj.org-article:ef7727a7311244f99efa5023622673d32021-11-25T16:50:26ZSex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism10.3390/biomedicines91116612227-9059https://doaj.org/article/ef7727a7311244f99efa5023622673d32021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1661https://doaj.org/toc/2227-9059The neuroimaging literature indicates that brain structure and function both deteriorate with diabetes, but information on sexual dimorphism in diabetes-related brain alterations is limited. This study aimed to ascertain whether brain metabolism is influenced by sex in an animal model of diabetes. Eleven rats (male, <i>n</i> = 5; female, <i>n</i> = 6) received a single intraperitoneal injection of 70 mg/kg streptozotocin (STZ) to develop diabetes. Another 11 rats (male, <i>n</i> = 5; female, <i>n</i> = 6) received the same amount of solvent through a single intraperitoneal injection. Longitudinal positron emission tomography scans were used to assess cerebral glucose metabolism before and 4 weeks after STZ or solvent administration. Before STZ or solvent injections, there was no evidence of sexual dimorphism in cerebral metabolism (<i>p</i> > 0.05). Compared with healthy control animals, rats with diabetes had significantly decreased brain metabolism in all brain regions (all <i>p</i> < 0.05). In addition, female diabetic rats exhibited further reduction in cerebral metabolism, relative to male diabetic rats (<i>p</i> < 0.05). The results of this study may provide some biological evidence, supporting the existence of a sexual dimorphism in diabetes-related complications.Chun-Yi WuYu-Hsin LinHsin-Hua HsiehJia-Jia LinShin-Lei PengMDPI AGarticlepositron emission tomography (PET)streptozotocin (STZ)<sup>18</sup>F-FDGhyperglycemiasexual dimorphismdiabetesBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1661, p 1661 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	positron emission tomography (PET) streptozotocin (STZ) <sup>18</sup>F-FDG hyperglycemia sexual dimorphism diabetes Biology (General) QH301-705.5
spellingShingle	positron emission tomography (PET) streptozotocin (STZ) <sup>18</sup>F-FDG hyperglycemia sexual dimorphism diabetes Biology (General) QH301-705.5 Chun-Yi Wu Yu-Hsin Lin Hsin-Hua Hsieh Jia-Jia Lin Shin-Lei Peng Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism
description	The neuroimaging literature indicates that brain structure and function both deteriorate with diabetes, but information on sexual dimorphism in diabetes-related brain alterations is limited. This study aimed to ascertain whether brain metabolism is influenced by sex in an animal model of diabetes. Eleven rats (male, <i>n</i> = 5; female, <i>n</i> = 6) received a single intraperitoneal injection of 70 mg/kg streptozotocin (STZ) to develop diabetes. Another 11 rats (male, <i>n</i> = 5; female, <i>n</i> = 6) received the same amount of solvent through a single intraperitoneal injection. Longitudinal positron emission tomography scans were used to assess cerebral glucose metabolism before and 4 weeks after STZ or solvent administration. Before STZ or solvent injections, there was no evidence of sexual dimorphism in cerebral metabolism (<i>p</i> > 0.05). Compared with healthy control animals, rats with diabetes had significantly decreased brain metabolism in all brain regions (all <i>p</i> < 0.05). In addition, female diabetic rats exhibited further reduction in cerebral metabolism, relative to male diabetic rats (<i>p</i> < 0.05). The results of this study may provide some biological evidence, supporting the existence of a sexual dimorphism in diabetes-related complications.
format	article
author	Chun-Yi Wu Yu-Hsin Lin Hsin-Hua Hsieh Jia-Jia Lin Shin-Lei Peng
author_facet	Chun-Yi Wu Yu-Hsin Lin Hsin-Hua Hsieh Jia-Jia Lin Shin-Lei Peng
author_sort	Chun-Yi Wu
title	Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism
title_short	Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism
title_full	Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism
title_fullStr	Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism
title_full_unstemmed	Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism
title_sort	sex differences in the effect of diabetes on cerebral glucose metabolism
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ef7727a7311244f99efa5023622673d3
work_keys_str_mv	AT chunyiwu sexdifferencesintheeffectofdiabetesoncerebralglucosemetabolism AT yuhsinlin sexdifferencesintheeffectofdiabetesoncerebralglucosemetabolism AT hsinhuahsieh sexdifferencesintheeffectofdiabetesoncerebralglucosemetabolism AT jiajialin sexdifferencesintheeffectofdiabetesoncerebralglucosemetabolism AT shinleipeng sexdifferencesintheeffectofdiabetesoncerebralglucosemetabolism
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Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism

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