Serum Nonesterified Fatty Acids and Incident Stroke: The CHS

Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum concentrations of nonesterified saturated, monounsaturated, poly...

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Autores principales:	Neil K. Huang, Mary L. Biggs, Nirupa R. Matthan, Luc Djoussé, W. T. Longstreth, Kenneth J. Mukamal, David S. Siscovick, Alice H. Lichtenstein
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cis‐7‐hexadecenoic acid dihomo‐γ‐linolenic acid incident stroke n‐3 PUFA nonesterified fatty acids Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/ef784397d508412ebe2df27c41896e04
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spelling	oai:doaj.org-article:ef784397d508412ebe2df27c41896e042021-11-16T10:22:43ZSerum Nonesterified Fatty Acids and Incident Stroke: The CHS10.1161/JAHA.121.0227252047-9980https://doaj.org/article/ef784397d508412ebe2df27c41896e042021-11-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.121.022725https://doaj.org/toc/2047-9980Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum concentrations of nonesterified saturated, monounsaturated, polyunsaturated, and trans fatty acids. Methods and Results CHS (Cardiovascular Health Study) participants (N=2028) who were free of stroke at baseline (1996–1997) and had an archived fasting serum sample were included in this study. A total of 35 NEFAs were quantified using gas chromatography. Cox proportional hazards regression models were used to evaluate associations of 5 subclasses (nonesterified saturated, monounsaturated, omega (n)‐6 polyunsaturated, n‐3 polyunsaturated, and trans fatty acids) of NEFAs and individual NEFAs with incident stroke. Sensitivity analysis was conducted by excluding cases with hemorrhagic stroke (n=45). A total of 338 cases of incident stroke occurred during the median 10.5‐year follow‐up period. Total n‐3 (hazard ratio [HR], 0.77 [95% CI, 0.61–0.97]) and n‐6 (HR, 1.32 [95% CI, 1.01–1.73]) subclasses of NEFA were negatively and positively associated with incident stroke, respectively. Among individual NEFAs, dihomo‐γ‐linolenic acid (20:3n‐6) was associated with higher risk (HR, 1.29 [95% CI, 1.02–1.63]), whereas cis‐7‐hexadecenoic acid (16:1n‐9c) and arachidonic acid (20:4n‐6) were associated with a lower risk (HR, 0.67 [95% CI, 0.47–0.97]; HR, 0.81 [95% CI. 0.65–1.00], respectively) of incident stroke per standard deviation increment. After the exclusion of cases with hemorrhagic stroke, these associations did not remain significant. Conclusions A total of 2 NEFA subclasses and 3 individual NEFAs were associated with incident stroke. Of these, the NEFA n‐3 subclass and dihomo‐γ‐linolenic acid are diet derived and may be potential biomarkers for total stroke risk.Neil K. HuangMary L. BiggsNirupa R. MatthanLuc DjousséW. T. LongstrethKenneth J. MukamalDavid S. SiscovickAlice H. LichtensteinWileyarticlecis‐7‐hexadecenoic aciddihomo‐γ‐linolenic acidincident stroken‐3 PUFAnonesterified fatty acidsDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cis‐7‐hexadecenoic acid dihomo‐γ‐linolenic acid incident stroke n‐3 PUFA nonesterified fatty acids Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cis‐7‐hexadecenoic acid dihomo‐γ‐linolenic acid incident stroke n‐3 PUFA nonesterified fatty acids Diseases of the circulatory (Cardiovascular) system RC666-701 Neil K. Huang Mary L. Biggs Nirupa R. Matthan Luc Djoussé W. T. Longstreth Kenneth J. Mukamal David S. Siscovick Alice H. Lichtenstein Serum Nonesterified Fatty Acids and Incident Stroke: The CHS
description	Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum concentrations of nonesterified saturated, monounsaturated, polyunsaturated, and trans fatty acids. Methods and Results CHS (Cardiovascular Health Study) participants (N=2028) who were free of stroke at baseline (1996–1997) and had an archived fasting serum sample were included in this study. A total of 35 NEFAs were quantified using gas chromatography. Cox proportional hazards regression models were used to evaluate associations of 5 subclasses (nonesterified saturated, monounsaturated, omega (n)‐6 polyunsaturated, n‐3 polyunsaturated, and trans fatty acids) of NEFAs and individual NEFAs with incident stroke. Sensitivity analysis was conducted by excluding cases with hemorrhagic stroke (n=45). A total of 338 cases of incident stroke occurred during the median 10.5‐year follow‐up period. Total n‐3 (hazard ratio [HR], 0.77 [95% CI, 0.61–0.97]) and n‐6 (HR, 1.32 [95% CI, 1.01–1.73]) subclasses of NEFA were negatively and positively associated with incident stroke, respectively. Among individual NEFAs, dihomo‐γ‐linolenic acid (20:3n‐6) was associated with higher risk (HR, 1.29 [95% CI, 1.02–1.63]), whereas cis‐7‐hexadecenoic acid (16:1n‐9c) and arachidonic acid (20:4n‐6) were associated with a lower risk (HR, 0.67 [95% CI, 0.47–0.97]; HR, 0.81 [95% CI. 0.65–1.00], respectively) of incident stroke per standard deviation increment. After the exclusion of cases with hemorrhagic stroke, these associations did not remain significant. Conclusions A total of 2 NEFA subclasses and 3 individual NEFAs were associated with incident stroke. Of these, the NEFA n‐3 subclass and dihomo‐γ‐linolenic acid are diet derived and may be potential biomarkers for total stroke risk.
format	article
author	Neil K. Huang Mary L. Biggs Nirupa R. Matthan Luc Djoussé W. T. Longstreth Kenneth J. Mukamal David S. Siscovick Alice H. Lichtenstein
author_facet	Neil K. Huang Mary L. Biggs Nirupa R. Matthan Luc Djoussé W. T. Longstreth Kenneth J. Mukamal David S. Siscovick Alice H. Lichtenstein
author_sort	Neil K. Huang
title	Serum Nonesterified Fatty Acids and Incident Stroke: The CHS
title_short	Serum Nonesterified Fatty Acids and Incident Stroke: The CHS
title_full	Serum Nonesterified Fatty Acids and Incident Stroke: The CHS
title_fullStr	Serum Nonesterified Fatty Acids and Incident Stroke: The CHS
title_full_unstemmed	Serum Nonesterified Fatty Acids and Incident Stroke: The CHS
title_sort	serum nonesterified fatty acids and incident stroke: the chs
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/ef784397d508412ebe2df27c41896e04
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Serum Nonesterified Fatty Acids and Incident Stroke: The CHS

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