Biomimetic Gut Model Systems for Development of Targeted Microbial Solutions for Enhancing Warfighter Health and Performance

ABSTRACT The human gut microbiome plays a vital role in both health and disease states and as a mediator of cognitive and physical performance. Despite major advances in our understanding of the role of gut microbes in host physiology, mechanisms underlying human-microbiome dynamics have yet to be f...

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Autores principales:	Lauren M. Brinkac, Nandita Rahman, Loun-Loun Chua, Sterling Thomas
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	coculture gut microbiome in vitro gut model systems warfighter operational readiness Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ef7b8d003be448028e5741388a89ff5b
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spelling	oai:doaj.org-article:ef7b8d003be448028e5741388a89ff5b2021-12-02T19:47:36ZBiomimetic Gut Model Systems for Development of Targeted Microbial Solutions for Enhancing Warfighter Health and Performance10.1128/mSystems.00487-202379-5077https://doaj.org/article/ef7b8d003be448028e5741388a89ff5b2020-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00487-20https://doaj.org/toc/2379-5077ABSTRACT The human gut microbiome plays a vital role in both health and disease states and as a mediator of cognitive and physical performance. Despite major advances in our understanding of the role of gut microbes in host physiology, mechanisms underlying human-microbiome dynamics have yet to be fully elucidated. This knowledge gap represents a major hurdle to the development of targeted gut microbiome solutions influencing human health and performance outcomes. The microbiome as it relates to warfighter health and performance is of interest to the Department of Defense (DoD) with the development of interventions impacting gut microbiome resiliency among its top research priorities. While technological advancements are enabling the development of experimental model systems that facilitate mechanistic insights underpinning human health, disease, and performance, translatability to human outcomes is still questionable. This review discusses some of the drivers influencing the DoD’s interest in the warfighter gut microbiome and describes current in vitro gut model systems supporting direct microbial-host interactions.Lauren M. BrinkacNandita RahmanLoun-Loun ChuaSterling ThomasAmerican Society for Microbiologyarticlecoculturegut microbiomein vitrogut model systemswarfighteroperational readinessMicrobiologyQR1-502ENmSystems, Vol 5, Iss 5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	coculture gut microbiome in vitro gut model systems warfighter operational readiness Microbiology QR1-502
spellingShingle	coculture gut microbiome in vitro gut model systems warfighter operational readiness Microbiology QR1-502 Lauren M. Brinkac Nandita Rahman Loun-Loun Chua Sterling Thomas Biomimetic Gut Model Systems for Development of Targeted Microbial Solutions for Enhancing Warfighter Health and Performance
description	ABSTRACT The human gut microbiome plays a vital role in both health and disease states and as a mediator of cognitive and physical performance. Despite major advances in our understanding of the role of gut microbes in host physiology, mechanisms underlying human-microbiome dynamics have yet to be fully elucidated. This knowledge gap represents a major hurdle to the development of targeted gut microbiome solutions influencing human health and performance outcomes. The microbiome as it relates to warfighter health and performance is of interest to the Department of Defense (DoD) with the development of interventions impacting gut microbiome resiliency among its top research priorities. While technological advancements are enabling the development of experimental model systems that facilitate mechanistic insights underpinning human health, disease, and performance, translatability to human outcomes is still questionable. This review discusses some of the drivers influencing the DoD’s interest in the warfighter gut microbiome and describes current in vitro gut model systems supporting direct microbial-host interactions.
format	article
author	Lauren M. Brinkac Nandita Rahman Loun-Loun Chua Sterling Thomas
author_facet	Lauren M. Brinkac Nandita Rahman Loun-Loun Chua Sterling Thomas
author_sort	Lauren M. Brinkac
title	Biomimetic Gut Model Systems for Development of Targeted Microbial Solutions for Enhancing Warfighter Health and Performance
title_short	Biomimetic Gut Model Systems for Development of Targeted Microbial Solutions for Enhancing Warfighter Health and Performance
title_full	Biomimetic Gut Model Systems for Development of Targeted Microbial Solutions for Enhancing Warfighter Health and Performance
title_fullStr	Biomimetic Gut Model Systems for Development of Targeted Microbial Solutions for Enhancing Warfighter Health and Performance
title_full_unstemmed	Biomimetic Gut Model Systems for Development of Targeted Microbial Solutions for Enhancing Warfighter Health and Performance
title_sort	biomimetic gut model systems for development of targeted microbial solutions for enhancing warfighter health and performance
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/ef7b8d003be448028e5741388a89ff5b
work_keys_str_mv	AT laurenmbrinkac biomimeticgutmodelsystemsfordevelopmentoftargetedmicrobialsolutionsforenhancingwarfighterhealthandperformance AT nanditarahman biomimeticgutmodelsystemsfordevelopmentoftargetedmicrobialsolutionsforenhancingwarfighterhealthandperformance AT lounlounchua biomimeticgutmodelsystemsfordevelopmentoftargetedmicrobialsolutionsforenhancingwarfighterhealthandperformance AT sterlingthomas biomimeticgutmodelsystemsfordevelopmentoftargetedmicrobialsolutionsforenhancingwarfighterhealthandperformance
_version_	1718376000291602432

Biomimetic Gut Model Systems for Development of Targeted Microbial Solutions for Enhancing Warfighter Health and Performance

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