Retinal microcirculation and leukocyte telomere length in the general population

Abstract Retinal arteriolar narrowing increases with age and predict adverse cardiovascular outcomes. Telomere length keeps track of the division of somatic cells and is a biomarker of biological age. We investigated to what extent retinal arteriolar diameters are associated with biological age, as...

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Autores principales:	Dries S. Martens, Fang-Fei Wei, Bianca Cox, Michelle Plusquin, Lutgarde Thijs, Ellen Winckelmans, Zhen-Yu Zhang, Tim S. Nawrot, Jan A. Staessen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef7bd0abf2d24d559802f55df43111f0
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spelling	oai:doaj.org-article:ef7bd0abf2d24d559802f55df43111f02021-12-02T12:32:35ZRetinal microcirculation and leukocyte telomere length in the general population10.1038/s41598-018-25165-62045-2322https://doaj.org/article/ef7bd0abf2d24d559802f55df43111f02018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25165-6https://doaj.org/toc/2045-2322Abstract Retinal arteriolar narrowing increases with age and predict adverse cardiovascular outcomes. Telomere length keeps track of the division of somatic cells and is a biomarker of biological age. We investigated to what extent retinal arteriolar diameters are associated with biological age, as captured by leukocyte telomere length (LTL). In 168 randomly selected Flemish participants from the family-based population study FLEMENGHO (mean age, 46.2 years) at baseline, of whom 85 underwent a follow-up examination (median, 4.1 years), we post-processed nonmydriatic retinal photographs and measured LTL. In men only, central retinal arteriolar equivalents (CRAE) and arteriole-to-venule ratio (AVR) were associated with LTL with stronger associations at higher age and body mass index. In men aged 57.6 years (75th percentile) a 20% shorter LTL was associated with a decrease in CRAE of 4.57 µm. A 20% shorter LTL was associated with a decrease of 5.88 µm in CRAE at a BMI of 29.9 kg/m2 (75th percentile). Similar associations were observed between AVR and LTL. In women, no retinal microvascular traits were associated with LTL. Retinal arteriolar narrowing in men but not in women is associated with biological age. Our findings support the idea that avoiding overweight contributes to maintaining a healthier microcirculation.Dries S. MartensFang-Fei WeiBianca CoxMichelle PlusquinLutgarde ThijsEllen WinckelmansZhen-Yu ZhangTim S. NawrotJan A. StaessenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dries S. Martens Fang-Fei Wei Bianca Cox Michelle Plusquin Lutgarde Thijs Ellen Winckelmans Zhen-Yu Zhang Tim S. Nawrot Jan A. Staessen Retinal microcirculation and leukocyte telomere length in the general population
description	Abstract Retinal arteriolar narrowing increases with age and predict adverse cardiovascular outcomes. Telomere length keeps track of the division of somatic cells and is a biomarker of biological age. We investigated to what extent retinal arteriolar diameters are associated with biological age, as captured by leukocyte telomere length (LTL). In 168 randomly selected Flemish participants from the family-based population study FLEMENGHO (mean age, 46.2 years) at baseline, of whom 85 underwent a follow-up examination (median, 4.1 years), we post-processed nonmydriatic retinal photographs and measured LTL. In men only, central retinal arteriolar equivalents (CRAE) and arteriole-to-venule ratio (AVR) were associated with LTL with stronger associations at higher age and body mass index. In men aged 57.6 years (75th percentile) a 20% shorter LTL was associated with a decrease in CRAE of 4.57 µm. A 20% shorter LTL was associated with a decrease of 5.88 µm in CRAE at a BMI of 29.9 kg/m2 (75th percentile). Similar associations were observed between AVR and LTL. In women, no retinal microvascular traits were associated with LTL. Retinal arteriolar narrowing in men but not in women is associated with biological age. Our findings support the idea that avoiding overweight contributes to maintaining a healthier microcirculation.
format	article
author	Dries S. Martens Fang-Fei Wei Bianca Cox Michelle Plusquin Lutgarde Thijs Ellen Winckelmans Zhen-Yu Zhang Tim S. Nawrot Jan A. Staessen
author_facet	Dries S. Martens Fang-Fei Wei Bianca Cox Michelle Plusquin Lutgarde Thijs Ellen Winckelmans Zhen-Yu Zhang Tim S. Nawrot Jan A. Staessen
author_sort	Dries S. Martens
title	Retinal microcirculation and leukocyte telomere length in the general population
title_short	Retinal microcirculation and leukocyte telomere length in the general population
title_full	Retinal microcirculation and leukocyte telomere length in the general population
title_fullStr	Retinal microcirculation and leukocyte telomere length in the general population
title_full_unstemmed	Retinal microcirculation and leukocyte telomere length in the general population
title_sort	retinal microcirculation and leukocyte telomere length in the general population
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ef7bd0abf2d24d559802f55df43111f0
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Retinal microcirculation and leukocyte telomere length in the general population

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