The Leptin Axis and Its Association With the Adaptive Immune System in Breast Cancer
Adipose tissue secretes various peptides, including leptin. This hormone acts through the leptin receptor (Ob-R), which is expressed ubiquitously on the surface of various cells, including breast cancer cells and immune cells. Increasing evidence points to an interaction between the tumor microenvir...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:ef83cb9a6bc64c839e9db2f3d11410e12021-11-15T04:57:03ZThe Leptin Axis and Its Association With the Adaptive Immune System in Breast Cancer1664-322410.3389/fimmu.2021.784823https://doaj.org/article/ef83cb9a6bc64c839e9db2f3d11410e12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.784823/fullhttps://doaj.org/toc/1664-3224Adipose tissue secretes various peptides, including leptin. This hormone acts through the leptin receptor (Ob-R), which is expressed ubiquitously on the surface of various cells, including breast cancer cells and immune cells. Increasing evidence points to an interaction between the tumor microenvironment, tumor cells, and the immune system. Leptin plays an important role in breast cancer tumorigenesis and may be implicated in activation of the immune system. While breast cancer cannot be considered an immunogenic cancer, the triple-negative subtype is an exception. Specific immune cells - tumor infiltrating lymphocytes - are involved in the immune response and act as predictive and prognostic factors in certain breast cancer subtypes. The aim of this article is to review the interaction between adipose tissue, through the expression of leptin and its receptor, and the adaptive immune system in breast cancer.Laura García-EstevezLaura García-EstevezLaura García-EstevezSilvia González-MartínezSilvia González-MartínezGema Moreno-BuenoGema Moreno-BuenoGema Moreno-BuenoFrontiers Media S.A.articleleptinleptin receptorbreast canceradaptive immunitytumor-infiltrating lymphocytes (TILs)Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
leptin leptin receptor breast cancer adaptive immunity tumor-infiltrating lymphocytes (TILs) Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
leptin leptin receptor breast cancer adaptive immunity tumor-infiltrating lymphocytes (TILs) Immunologic diseases. Allergy RC581-607 Laura García-Estevez Laura García-Estevez Laura García-Estevez Silvia González-Martínez Silvia González-Martínez Gema Moreno-Bueno Gema Moreno-Bueno Gema Moreno-Bueno The Leptin Axis and Its Association With the Adaptive Immune System in Breast Cancer |
| description |
Adipose tissue secretes various peptides, including leptin. This hormone acts through the leptin receptor (Ob-R), which is expressed ubiquitously on the surface of various cells, including breast cancer cells and immune cells. Increasing evidence points to an interaction between the tumor microenvironment, tumor cells, and the immune system. Leptin plays an important role in breast cancer tumorigenesis and may be implicated in activation of the immune system. While breast cancer cannot be considered an immunogenic cancer, the triple-negative subtype is an exception. Specific immune cells - tumor infiltrating lymphocytes - are involved in the immune response and act as predictive and prognostic factors in certain breast cancer subtypes. The aim of this article is to review the interaction between adipose tissue, through the expression of leptin and its receptor, and the adaptive immune system in breast cancer. |
| format |
article |
| author |
Laura García-Estevez Laura García-Estevez Laura García-Estevez Silvia González-Martínez Silvia González-Martínez Gema Moreno-Bueno Gema Moreno-Bueno Gema Moreno-Bueno |
| author_facet |
Laura García-Estevez Laura García-Estevez Laura García-Estevez Silvia González-Martínez Silvia González-Martínez Gema Moreno-Bueno Gema Moreno-Bueno Gema Moreno-Bueno |
| author_sort |
Laura García-Estevez |
| title |
The Leptin Axis and Its Association With the Adaptive Immune System in Breast Cancer |
| title_short |
The Leptin Axis and Its Association With the Adaptive Immune System in Breast Cancer |
| title_full |
The Leptin Axis and Its Association With the Adaptive Immune System in Breast Cancer |
| title_fullStr |
The Leptin Axis and Its Association With the Adaptive Immune System in Breast Cancer |
| title_full_unstemmed |
The Leptin Axis and Its Association With the Adaptive Immune System in Breast Cancer |
| title_sort |
leptin axis and its association with the adaptive immune system in breast cancer |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/ef83cb9a6bc64c839e9db2f3d11410e1 |
| work_keys_str_mv |
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